ArticleExperimental gerontology2010
Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects.
Article in Experimental gerontology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Sex Disparities in P53 Regulation and Functions: Novel Insights for Personalized Cancer Therapies.Cells · 2025Review
- Selectively advantageous instability in biotic and pre-biotic systems and implications for evolution and aging.Frontiers in aging · 2024Review
- Identification and expression analysis of heat shock protein family genes of gall fly (Procecidochares utilis) under temperature stress.Cell stress & chaperones · 2023Article
- Sex differences in the response to oxidative and proteolytic stress.Redox biology · 2020Review
- Perturbation of IIS/TOR signaling alters the landscape of sex-differential gene expression in Drosophila.BMC genomics · 2018Article
- The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress.Current biology : CB · 2017Article
- Multiple Metazoan Life-span Interventions Exhibit a Sex-specific Strehler-Mildvan Inverse Relationship Between Initial Mortality Rate and Age-dependent Mortality Rate Acceleration.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Article
- The FoxO3 gene and cause-specific mortality.Aging cell · 2016Article
- Mitochondrial maintenance failure in aging and role of sexual dimorphism.Archives of biochemistry and biophysics · 2015Review
- Article
- Drosophila melanogaster Hsp22: a mitochondrial small heat shock protein influencing the aging process.Frontiers in genetics · 2015Review
- Examination of the genetic basis for sexual dimorphism in the Aedes aegypti (dengue vector mosquito) pupal brain.Biology of sex differences · 2014Article
- Genomic response to selection for postponed senescence in Drosophila.Mechanisms of ageing and development · 2013Article
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- Article
- Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling.Molecular systems biology · 2011Article
- dSir2 and longevity in Drosophila.Experimental gerontology · 2011Review
- Heat shock proteins and Drosophila aging.Experimental gerontology · 2011Review
- The genetic architecture of aging: sexual antagonistic pleiotropy of p53 and foxo.Cell cycle (Georgetown, Tex.) · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sex-specific selective pressures are hypothesized to lead to sexually antagonistic gene functions that contribute to phenotypes such as aging and cancer. However, relatively little is known about the identity of such genes and possible mechanisms. Here we report that nervous system-specific over-expression of wild-type p53 in Drosophila caused decreased life span in males and increased life span in females. In contrast, tissue-general over-expression produced the opposite pattern: increased life span in males and decreased life span in females. In a foxo null background, p53 life span effects in males were reversed, becoming similar to the effects in females. In contrast, a Sir2 null background tended to reduce the magnitude of p53 effects. The data demonstrate that wild-type p53 over-expression can regulate life span independent of foxo, and suggest that foxo acts in males to produce sexually antagonistic life span effects of p53.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.