ArticleTranslational research : the journal of laboratory and clinical medicine2009
Gammadelta T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosis.
Article in Translational research : the journal of laboratory and clinical medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host.Reviews in medical virology · 2026Review
- Longstanding hypersensitivity pneumonitis and its response to roflumilast: A review of its likely immunological effects.Respiratory medicine case reports · 2022Article
- Air pollution-induced epigenetic changes: disease development and a possible link with hypersensitivity pneumonitis.Environmental science and pollution research international · 2021Review
- Chronic Occupational Mold Exposure Drives Expansion ofJournal of fungi (Basel, Switzerland) · 2021Article
- Host-Related Laboratory Parameters for Leprosy Reactions.Frontiers in medicine · 2021Review
- γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces.Immunological reviews · 2020Review
- Genetic variability of T cell responses in hypersensitivity pneumonitis identified using the BXD genetic reference panel.American journal of physiology. Lung cellular and molecular physiology · 2020Article
- T Cells in Fibrosis and Fibrotic Diseases.Frontiers in immunology · 2020Review
- Enterovirus D68 infection induces IL-17-dependent neutrophilic airway inflammation and hyperresponsiveness.JCI insight · 2018Article
- VMediators of inflammation · 2018Article
- IL-17 in the lung: the good, the bad, and the ugly.American journal of physiology. Lung cellular and molecular physiology · 2018Review
- The Th1/Th17 balance dictates the fibrosis response in murine radiation-induced lung disease.Scientific reports · 2017Article
- Vaccinia vaccine-based immunotherapy arrests and reverses established pulmonary fibrosis.JCI insight · 2016Article
- Does IL-17 Respond to the Disordered Lung Microbiome and Contribute to the Neutrophilic Phenotype in Asthma?Mediators of inflammation · 2016Review
- Polymorphisms in interleukin 17A gene and coal workers' pneumoconiosis risk in a Chinese population.BMC pulmonary medicine · 2015Article
- Conversion of bone marrow mesenchymal stem cells into type II alveolar epithelial cells reduces pulmonary fibrosis by decreasing oxidative stress in rats.Molecular medicine reports · 2015Article
- CD4(+) T-cell subsets and host defense in the lung.Immunological reviews · 2013Review
- TLR2 regulates neutrophil recruitment and cytokine production with minor contributions from TLR9 during hypersensitivity pneumonitis.PloS one · 2013Article
- Immunomodulation at epithelial sites by obesity and metabolic disease.Immunologic research · 2012Review
- T-bet controls severity of hypersensitivity pneumonitis.Journal of inflammation (London, England) · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Hypersensitivity pneumonitis (HP) is an inflammatory lung disease caused by the repeated inhalation of aerosolized antigens. With chronic exposure to an inhaled antigen, patients are at risk of developing irreversible pulmonary fibrosis as well as an increased morbidity and mortality. Although alphabeta T cells have been shown to be important in the pathogenesis of HP, gammadelta T cells also accumulate in the bronchoalveolar lavage of patients with HP. gammadelta T cells represent a distinct lymphocyte subset, whose primary function is not well understood. In contrast to alphabeta T cells, gammadelta T cells recognize unprocessed antigens, such as those upregulated on injured or stressed epithelial cells. In a murine model of HP induced by exposure to the ubiquitous microorganism Bacillus subtilis, gammadelta T cells expressing the canonical Vgamma6/Vdelta1 T cell receptor were dramatically expanded in the lung. The predominant cytokines expressed by this gammadelta T-cell subset were T-helper 17 (Th17) cytokines that were critical for bacterial clearance and the resolution of lung inflammation. Th17-expressing gammadelta T cells are also expanded in other murine models of lung infection and inflammation, which suggests that these cells play a sentinel role in mucosal immunity. Thus, an increased understanding of gammadelta T cells that express Th17 cytokines in HP and other inflammatory lung diseases may lead to the development of novel therapeutic and clinical strategies that prevent the development of fibrotic lung disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.