ArticleMalaria journal2009
Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria.
Article in Malaria journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- A fine mapping of single nucleotide variants and haplotype analysis ofFrontiers in immunology · 2023Article
- IL-4 gene polymorphisms and their association with nematodes infection in Pakistani population.African health sciences · 2022Article
- Pan-cancer chromatin analysis of the human vtRNA genes uncovers their association with cancer biology.F1000Research · 2021Article
- Host genetic polymorphisms and serological response against malaria in a selected population in Sri Lanka.Malaria journal · 2018Article
- Host genetics in malaria: lessons from mouse studies.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- A genome scan for Plasmodium falciparum malaria identifies quantitative trait loci on chromosomes 5q31, 6p21.3, 17p12, and 19p13.Malaria journal · 2014Article
- Neuregulin-1 attenuates mortality associated with experimental cerebral malaria.Journal of neuroinflammation · 2014Article
- Genetic polymorphisms associated with anti-malarial antibody levels in a low and unstable malaria transmission area in southern Sri Lanka.Malaria journal · 2012Article
- Article
- The host genetic diversity in malaria infection.Journal of tropical medicine · 2012Article
- Duality and complexity of allergic type inflammatory mechanisms in determining the outcome of malaria disease.Frontiers in immunology · 2011Article
- Genome-wide significant linkage to IgG subclass responses against Plasmodium falciparum antigens on chromosomes 8p22-p21, 9q34 and 20q13.Genes and immunityArticle
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been previously demonstrated that a single nucleotide polymorphism (SNP) in the IL13 promoter region, IL13 -1055T>C (rs1800925), was associated with susceptibility to severe malaria in Thais. In the present study, fine association mapping for a cytokine gene cluster including IL4, IL5, and IL13 on chromosome 5q31 was conducted using the same malaria subjects to refine the region containing a primary variant or a haplotype susceptible to severe malaria.
methodsA total of 82 SNPs spanning 522 kb of the 5q31 region were analysed in 368 patients with Plasmodium falciparum malaria (203 mild malaria and 165 severe malaria patients).
resultsOnly rs1881457 located in the promoter region of IL13, which is in linkage disequilibrium with rs1800925 (r2 = 0.73), showed a significant association with severe malaria after adjusting for multiple testing (P = 0.046 by permutation test). This SNP was in a haplotype block spanning 97 kb (from rs2069812 to rs2240032). The detected haplotype block contained the RAD50 gene and the promoter of IL13, but not the other genes.
conclusionA haplotype block in which a primary polymorphism associated with severe malaria is likely to be encoded was identified in Thai malaria patients.
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