ArticleJournal of neuroendocrinology2009
Oestradiol and insulin-like growth factor-1 reduce cell loss after global ischaemia in middle-aged female rats.
Article in Journal of neuroendocrinology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Mechanisms of estrogens' dose-dependent neuroprotective and neurodamaging effects in experimental models of cerebral ischemia.International journal of molecular sciences · 2011Pooled it
- Aucubin Exerts Neuroprotection against Forebrain Ischemia and Reperfusion Injury in Gerbils through Antioxidative and Neurotrophic Effects.Antioxidants (Basel, Switzerland) · 2023Article
- Time dependent impact of perinatal hypoxia on growth hormone, insulin-like growth factor 1 and insulin-like growth factor binding protein-3.Metabolic brain disease · 2016Article
- Neuroprotective effects of enriched environment housing after transient global cerebral ischaemia are associated with the upregulation of insulin-like growth factor-1 signalling.Neuropathology and applied neurobiology · 2015Article
- Estrogen-IGF-1 interactions in neuroprotection: ischemic stroke as a case study.Frontiers in neuroendocrinology · 2015Review
- The comparison of anticancer activity of thymoquinone and nanothymoquinone on human breast adenocarcinoma.Iranian journal of pharmaceutical research : IJPR · 2015Article
- Stroke neuroprotection: oestrogen and insulin-like growth factor-1 interactions and the role of microglia.Journal of neuroendocrinology · 2013Review
- Neuroprotective action of acute estrogens: animal models of brain ischemia and clinical implications.Steroids · 2013Review
- Revisiting the timing hypothesis: biomarkers that define the therapeutic window of estrogen for stroke.Hormones and behavior · 2013Review
- Article
- Effects of global ischemia and estradiol pretreatment on phosphorylation of Akt, CREB and STAT3 in hippocampal CA1 of young and middle-aged female rats.Brain research · 2012Article
- Neuroprotective actions of estradiol and novel estrogen analogs in ischemia: translational implications.Frontiers in neuroendocrinology · 2011Review
- 14-3-3gamma and neuroglobin are new intrinsic protective factors for cerebral ischemia.Molecular neurobiology · 2010Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Whereas the ability of oestradiol and insulin-like growth factor (IGF)-1 to afford neuroprotection against ischaemia-induced neuronal death in young female and male rodents is well established, the impact of IGF-1 in middle-aged animals is largely unknown. The present study assessed the efficacy of oestradiol and IGF-1 with respect to reducing neuronal death after transient global ischaemia in middle-aged female rats after 8 weeks of hormone withdrawal. Rats were ovariohysterectomised and implanted 8 weeks later with an osmotic mini-pump delivering IGF-1 or saline into the lateral ventricle. Some rats also received physiological levels of oestradiol by subcutaneous pellet. Two weeks later, rats were subjected to global ischaemia or sham operation. Surviving hippocampal CA1 neurones were quantified. Ischaemia produced massive CA1 cell death compared to sham-operated animals, which was evident at 14 days. Significantly more neurones survived in animals treated with either oestradiol or IGF-1, but simultaneous treatment produced no additive effect. IGF-1, an endogenous growth factor, may be a clinically useful therapy in preventing human brain injury, with neuroprotective equivalence to oestradiol but without the harmful side-effects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.