ArticleJournal of cellular and molecular medicine2011
Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin.
Article in Journal of cellular and molecular medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- Contribution of gelsolin and its secretory isoform to the migratory properties of neural crest and DRG cells in the chicken embryo.Frontiers in molecular neuroscience · 2026Article
- Skin melanoma cells produce diverse gelsolin (GSN) isoforms, which play non-redundant roles in cells' proliferation and motility.Cancer cell international · 2025Article
- Emerging roles of plasma gelsolin in tumorigenesis and modulating the tumor microenvironment.The Kaohsiung journal of medical sciences · 2022Review
- Plasma gelsolin modulates the production and fate of IL-1β-containing microparticles following high-pressure exposure and decompression.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- The exosome-mediated autocrine and paracrine actions of plasma gelsolin in ovarian cancer chemoresistance.Oncogene · 2020Article
- Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target.International journal of molecular sciences · 2018Review
- The journey of antiphospholipid antibodies from cellular activation to antiphospholipid syndrome.Current rheumatology reports · 2015Review
- Plasma gelsolin accumulates in macrophage nodules in brains of simian immunodeficiency virus infected rhesus macaques.Journal of neurovirology · 2012Article
- Elucidating protein inter- and intramolecular interacting domains using chemical cross-linking and matrix-assisted laser desorption ionization-time of flight/time of flight mass spectrometry.Analytical biochemistry · 2012Article
- Identification of secretory gelsolin as a plasma biomarker associated with distant organ metastasis of colorectal cancer.Journal of molecular medicine (Berlin, Germany) · 2012Article
- Mass spectrometric characterization of gelsolin isoforms.Rapid communications in mass spectrometry : RCM · 2010Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antiphospholipid syndrome (APS) is characterized by thrombosis and the presence of antiphospholipid antibodies (aPL) that directly recognizes plasma β(2)-glycoprotein I (β(2) GPI). Tissue factor (TF), the major initiator of the extrinsic coagulation system, is induced on monocytes by aPL in vitro, explaining in part the pathophysiology in APS. We previously reported that the mitogen-activated protein kinase (MAPK) pathway plays an important role in aPL-induced TF expression on monocytes. In this study, we identified plasma gelsolin as a protein associated with β(2) GPI by using immunoaffinity chromatography and mass spectrometric analysis. An in vivo binding assay showed that endogenous β(2) GPI interacts with plasma gelsolin, which binds to integrin a(5) β(1) through fibronectin. The tethering of β(2) GPI to monoclonal anti-β(2) GPI autoantibody on the cell surface was enhanced in the presence of plasma gelsolin. Immunoblot analysis demonstrated that p38 MAPK protein was phosphorylated by monoclonal anti-β(2) GPI antibody treatment, and its phosphorylation was attenuated in the presence of anti-integrin a(5) β(1) antibody. Furthermore, focal adhesion kinase, a downstream molecule of the fibronectin-integrin signalling pathway, was phosphorylated by anti-β(2) GPI antibody treatment. These results indicate that molecules including gelsolin and integrin are involved in the anti-β(2) GPI antibody-induced MAPK pathway on monocytes and that integrin is a possible therapeutic target to modify a prothrombotic state in patients with APS.
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