ArticleBipolar disorders2009
Sexually dimorphic features of vermis morphology in bipolar disorder.
Article in Bipolar disorders, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Identifying transdiagnostic neurobiomarkers for precision major psychiatric disordersJournal of translational internal medicine · 2026Article
- Cerebellar structure is abnormal in schizophrenia and deviates from bipolar disorder.NeuroImage. Clinical · 2026Article
- Sex differences in anhedonia in bipolar depression: a resting-state fMRI study.European archives of psychiatry and clinical neuroscience · 2025Article
- A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults.Journal of affective disorders · 2022Article
- A graph theory-based whole brain approach to assess mood state differences in adolescents and young adults with bipolar disorder.Bipolar disorders · 2022Article
- Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies.Molecular psychiatry · 2020Review
- Age-specific effects of structural and functional connectivity in prefrontal-amygdala circuitry in women with bipolar disorder.BMC psychiatry · 2018Article
- Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states.Brain imaging and behavior · 2018Article
- Aberrant cerebellar connectivity in bipolar disorder with psychosis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features.Acta psychiatrica Scandinavica · 2015Article
- Alterations in amplitude of low frequency fluctuation in treatment-naïve major depressive disorder measured with resting-state fMRI.Human brain mapping · 2014Article
- Posterior cerebellar vermal deficits in bipolar disorder.Journal of affective disorders · 2013Article
- Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala-anterior paralimbic neural system.Bipolar disorders · 2012Review
- Lateral ventricle volume and psychotic features in adolescents and adults with bipolar disorder.Psychiatry research · 2011Article
- Olfactocentric paralimbic cortex morphology in adolescents with bipolar disorder.Brain : a journal of neurology · 2011Article
- A functional MRI study of working memory in adolescents and young adults at genetic risk for bipolar disorder: preliminary findings.Bipolar disorders · 2011Article
- Neurochemical deficits in the cerebellar vermis in child offspring of parents with bipolar disorder.Bipolar disorders · 2011Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesThe cerebellar vermis is increasingly implicated in bipolar disorder (BD). In this study, we investigated vermis morphology in BD using a quantitative volumetric analysis.
methodsVolumes for total vermis and vermis subregions V1 (lobules I-V), V2 (lobules VI-VII), and V3 (lobules VIII-X) were calculated using high-resolution structural magnetic resonance imaging obtained from 44 individuals with BD (25 females and 19 males) and 43 healthy comparison (HC) subjects (26 females and 17 males). Total vermis volumes were compared between the BD and HC groups. Potential effects of vermis subregions and clinical features were explored.
resultsTotal vermis volumes were significantly larger in the BD group than in the HC group (p = 0.02). There was a significant group-by-sex interaction (p = 0.02). Total vermis volumes were significantly larger in males with BD than HC males (p = 0.004); vermis volumes did not differ significantly between females with and without BD (p = 0.95). Subregion analyses showed a trend-level interaction between diagnosis and subregion (p = 0.07) in which subregion V1 volumes were significantly larger in BD participants (p = 0.001), with differences primarily driven by males (p = 0.001).
conclusionsOur findings demonstrate increases in cerebellar vermis volumes in males with BD. These findings support the presence of structural alterations in the cerebellar vermis in BD and furthermore the influence of sex on such changes.
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