ArticleASN neuro2009
Animal models for Alzheimer's disease and frontotemporal dementia: a perspective.
Article in ASN neuro, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed.
- Ayurvedic formulations Guduchi and Madhuyashti triggers JNK signaling mediated immune response and adversely affects Huntington phenotype.BMC complementary medicine and therapies · 2022Article
- Let-7c increases BACE2 expression by RNAa and decreases Aβ production.American journal of translational research · 2022Article
- Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders.Neuroscience and biobehavioral reviews · 2022Review
- Characterization of an APP/tau rat model of Alzheimer's disease by positron emission tomography and immunofluorescent labeling.Alzheimer's research & therapy · 2021Article
- Preclinical Marmoset Model for Targeting Chronic Inflammation as a Strategy to Prevent Alzheimer's Disease.Vaccines · 2021Review
- Reconstruction of Alzheimer's Disease Cell ModelStem cells international · 2020Article
- Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer's disease animal model.Journal of neuroinflammation · 2019Article
- Knockout of p75 neurotrophin receptor attenuates the hyperphosphorylation of Tau in pR5 mouse model.Aging · 2019Article
- Hesperetin Confers Neuroprotection by Regulating Nrf2/TLR4/NF-κB Signaling in an Aβ Mouse Model.Molecular neurobiology · 2019Article
- Physiological Aβ Concentrations Produce a More Biomimetic Representation of the Alzheimer's Disease Phenotype in iPSC Derived Human Neurons.ACS chemical neuroscience · 2018Article
- Co-administration of 3-Acetyl-11-Keto-Beta-Boswellic Acid Potentiates the Protective Effect of Celecoxib in Lipopolysaccharide-Induced Cognitive Impairment in Mice: Possible Implication of Anti-inflammatory and Antiglutamatergic Pathways.Journal of molecular neuroscience : MN · 2016Article
- Accurate molecular imaging of small animals taking into account animal models, handling, anaesthesia, quality control and imaging system performance.EJNMMI physics · 2015Article
- Challenges of multimorbidity of the aging brain: a critical update.Journal of neural transmission (Vienna, Austria : 1996) · 2015Review
- Effect of licofelone--a dual COX/5-LOX inhibitor in intracerebroventricular streptozotocin-induced behavioral and biochemical abnormalities in rats.Journal of molecular neuroscience : MN · 2015Article
- A review of β-amyloid neuroimaging in Alzheimer's disease.Frontiers in neuroscience · 2014Review
- Lessons from two prevalent amyloidoses-what amylin and Aβ have in common.Frontiers in aging neuroscience · 2013Article
- What Renders TAU Toxic.Frontiers in neurology · 2013Article
- Alzheimer's disease models and functional genomics-How many needles are there in the haystack?Frontiers in physiology · 2012Article
- Age-related changes of neuron numbers in the frontal cortex of a transgenic mouse model of Alzheimer's disease.Brain structure & function · 2011Article
- Neuroinflammation, microglia and implications for anti-inflammatory treatment in Alzheimer's disease.International journal of Alzheimer's disease · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In dementia research, animal models have become indispensable tools. They not only model aspects of the human condition, but also simulate processes that occur in humans and hence provide insight into how disease is initiated and propagated. The present review discusses two prominent human neurodegenerative disorders, Alzheimer's disease and frontotemporal dementia. It discusses what we would like to model in animals and highlights some of the more recent achievements using species as diverse as mice, fish, flies and worms. Advances in imaging and therapy are explored. We also discuss some anticipated new models and developments. These will reveal how key players in the pathogenesis of Alzheimer's disease and frontotemporal dementia, such as the peptide Aβ (amyloid β) and the protein tau, cause neuronal dysfunction and eventually, neuronal demise. Understanding these processes fully will lead to early diagnosis and therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.