ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2010
Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Association between phosphorus intake and wrist fracture: the mediating role of bone mineral density.Food & nutrition research · 2026Article
- Exploring indigenous knowledge and practices of the Gurage community on the biosystematics and utilization of Enset landraces for bone fracture and regeneration: the case of Gurage Zone, central Ethiopia region.Frontiers in pharmacology · 2025Article
- Relationships between matrix mineralization, oxidative metabolism, and mitochondrial structure during ATDC5 murine chondroprogenitor cell line differentiation.Journal of cellular physiology · 2024Article
- Refeeding partially reverses impaired fracture callus in undernourished rats.Frontiers in endocrinology · 2024Article
- Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation.Bone reports · 2023Article
- Prx1 cell subpopulations identified in various tissues with diverse quiescence and activation ability following fracture and BMP2 stimulation.Frontiers in physiology · 2023Article
- An investigation of the effect of acrylamide on fracture healing in rats.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- An Expert Perspective on Phosphate Dysregulation With a Focus on Chronic Hypophosphatemia.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Lepidium sativum: Bone healer in traditional medicine, an experimental validation study in rats.Journal of family medicine and primary care · 2020Article
- Clustering of temporal gene expression data with mixtures of mixed effects models with a penalized likelihood.Bioinformatics (Oxford, England) · 2019Article
- Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm.Scientific reports · 2018Article
- Molecular pathogenesis of fracture nonunion.Journal of orthopaedic translation · 2018Review
- Transcriptional Mechanisms of Secondary Fracture Healing.Current osteoporosis reports · 2018Review
- Correlation between RUST assessments of fracture healing to structural and biomechanical properties.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Mouse models of bone healing: fracture, marrow ablation, and distraction osteogenesis.Current protocols in mouse biology · 2015Article
- Generation of closed transverse fractures in small animals.Methods in molecular biology (Clifton, N.J.) · 2014Article
- The significance of serum phosphate level on healing index and its relative effects in skeletally immature and mature patients with hypophosphatemic rickets.BioMed research international · 2014Article
- A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo.The Journal of biological chemistry · 2012Article
- The biology of fracture healing.Injury · 2011Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Hypophosphatemia leads to rickets and osteomalacia, the latter of which results in decreased biomechanical integrity of bones, accompanied by poor fracture healing. Impaired phosphate-dependent apoptosis of hypertrophic chondrocytes is the molecular basis for rickets. However, the underlying pathophysiology of impaired fracture healing has not been characterized previously. To address the role of phosphate in fracture repair, mice were placed on a phosphate-restricted diet 2 days prior to or 3 days after induction of a mid-diaphyseal femoral fracture to assess the effects of phosphate deficiency on the initial recruitment of mesenchymal stem cells and their subsequent differentiation. Histologic and micro-computed tomographic (microCT) analyses demonstrated that both phosphate restriction models dramatically impaired fracture healing primarily owing to a defect in differentiation along the chondrogenic lineage. Based on Sox9 and Sox5 mRNA levels, neither the initial recruitment of cells to the callus nor their lineage commitment was effected by hypophosphatemia. However, differentiation of these cells was impaired in association with impaired bone morphogenetic protein (BMP) signaling. In vivo ectopic bone-formation assays and in vitro investigations in ST2 stromal cells confirmed that phosphate restriction leads to BMP-2 resistance. Marrow ablation studies demonstrate that hypophosphatemia has different effects on injury-induced intramembranous bone formation compared with endochondral bone formation. Thus phosphate plays an important role in the skeleton that extends beyond mineralized matrix formation and growth plate maturation and is critical for endochondral bone repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.