ArticleCell stress & chaperones2010
Polymorphisms in the HSP90AA1 5' flanking region are associated with scrapie incubation period in sheep.
Article in Cell stress & chaperones, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- From markers to mechanisms: a comprehensive review of major genes and quantitative trait loci shaping the modern sheep (Frontiers in genetics · 2026Review
- Validation of SNP markers for thermotolerance adaptation in Ovis aries adapted to different climatic regions using KASP-PCR technique.Scientific reports · 2022Article
- A novel T177P missense variant in the HSPA8 gene associated with the low tolerance of Awassi sheep to heat stress.Tropical animal health and production · 2020Article
- Association of heat stress protein 90 and 70 gene polymorphism with adaptability traits in Indian sheep (Ovis aries).Cell stress & chaperones · 2017Article
- In silico analysis of regulatory and structural motifs of the ovine HSP90AA1 gene.Cell stress & chaperones · 2016Article
- The polymorphisms in the promoter of HSP90 gene and their association with heat tolerance of bay scallop.Cell stress & chaperones · 2015Article
- Looking for adaptive footprints in the HSP90AA1 ovine gene.BMC evolutionary biology · 2015Article
- Article
- What can livestock breeders learn from conservation genetics and vice versa?Frontiers in genetics · 2015Review
- Influence of the temperature and the genotype of the HSP90AA1 gene over sperm chromatin stability in Manchega Rams.PloS one · 2014Article
- Ovine HSP90AA1 expression rate is affected by several SNPs at the promoter under both basal and heat stress conditions.PloS one · 2013Article
- Article
- Analysis of genetic variability at codon 42 within caprine prion protein gene in relation to production traits in Chinese domestic breeds.Molecular biology reports · 2012Article
- Changes in HSP gene and protein expression in natural scrapie with brain damage.Veterinary research · 2011Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Susceptibility to scrapie is mainly controlled by point mutations at the PRNP locus. However, additional quantitative trait loci (QTL) have been identified across the genome including a region in OAR18. The gene which encodes the inducible form of the cytoplasmic Hsp90 chaperone (HSP90AA1) maps within this region and seems to be associated with the resistance/susceptibility to scrapie in sheep. Here, we have analyzed several polymorphisms which were previously described in the ovine HSP90AA1 5' flanking region and in intron 10 in two naturally scrapie infected Romanov sheep populations. First, we have studied 58 ARQ/VRQ animals pertaining to the sire family where the QTL influencing scrapie incubation period in OAR18 was detected. We have found a significant association between polymorphisms localized at -660 and -528 in the HSP90AA1 5' flanking region and the scrapie incubation period. These two polymorphisms have also been studied in a second sample constituted by 62 VRQ/VRQ sheep showing an extreme incubation period. Results are concordant with the first dataset. Finally, we have studied the HSP90AA1 expression in scrapie and control animals (N = 41) with different HSP90AA1 genotypes by real time PCR on blood samples. The HSP90AA1 expression rate was equivalent in CC(-600)AA(-528) and CG(-600)AG(-528) scrapie resistant animals (ARR/ARR) and was higher in their CC(-600)AA(-528) than in their CG(-600)AG(-528) scrapie susceptible counterparts (VRQ/VRQ). Our results support the hypothesis that the ovine HSP90AA1 gene acts as a modulator of scrapie susceptibility, contributing to the observed differences in the incubation period of scrapie infected animals with the same PRNP genotype.
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