ArticleMetabolic brain disease2009
A proteomic analysis of the ventral hippocampus of rats subjected to maternal separation and escitalopram treatment.
Article in Metabolic brain disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 50 citations in OpenAlex.
- The Emerging Role of the DDAH Proteins in Psychiatric Disorders.Biological psychiatry global open science · 2025Review
- Article
- Connecting Dots between Mitochondrial Dysfunction and Depression.Biomolecules · 2023Review
- Early Adversity and Accelerated Brain Aging: A Mini-Review.Frontiers in molecular neuroscience · 2022Review
- Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults.Neurobiology of stress · 2020Article
- Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry.BMC psychiatry · 2020Article
- Combined Metabolomics and Proteomics Analysis of Major Depression in an Animal Model: Perturbed Energy Metabolism in the Chronic Mild Stressed Rat Cerebellum.Omics : a journal of integrative biology · 2015Article
- What Have Mass Spectrometry-Based Proteomics and Metabolomics (Not) Taught Us about Psychiatric Disorders?Molecular neuropsychiatry · 2015Review
- Synaptoproteomic analysis of a rat gene-environment model of depression reveals involvement of energy metabolism and cellular remodeling pathways.The international journal of neuropsychopharmacology · 2014Article
- Chronic exposure to light reverses the effect of maternal separation on proteins in the prefrontal cortex.Journal of molecular neuroscience : MN · 2013Article
- Effects of maternal separation and methamphetamine exposure on protein expression in the nucleus accumbens shell and core.Metabolic brain disease · 2012Article
- Article
- Chronic agomelatine treatment corrects behavioral, cellular, and biochemical abnormalities induced by prenatal stress in rats.Psychopharmacology · 2011Article
- Chronic escitalopram treatment restores spatial learning, monoamine levels, and hippocampal long-term potentiation in an animal model of depression.Psychopharmacology · 2011Article
- Pharmacogenomics of suicidal events.Pharmacogenomics · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Early life stress is known to predispose humans to the development of depression. Developmental stress has been shown to cause various changes in neurotransmitter systems, neurotrophin expression and the hypothalamic pituitary adrenal-axis in the rat brain. The aim of this study was to identify which cytosolic proteins are altered by maternal separation, as a model for depression, as well as by chronic antidepressant treatment. Rats were maternally separated from postnatal day 2-14 for 3 h per day while control rats were normally reared. Both groups were divided and received either escitalopram or saline injections for 6 weeks starting from postnatal day 40. The ventral hippocampal tissue was fractionated and the cytosolic fraction used for 2-D-gel electrophoresis and liquid chromatography coupled to mass spectrometry analyses to identify peptides. Mascot database searches were done to identify proteins that were differentially expressed between the groups. Proteins that were significantly changed by maternal separation included amongst others: molecular chaperones and proteins related to energy metabolism; neuroplasticity; oxidative stress regulation; and protein metabolism. Treatment with escitalopram, a selective-serotonin reuptake inhibitor, induced changes in a different group of proteins, except for a few involved in energy metabolism and neuroprotective pathways. The results indicate which cytosolic proteins are changed by early life stress and may therefore be involved in the development of depression.
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Registered trials
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