ArticleImmunogenetics2009
Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503.
Article in Immunogenetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Evidence of focusing the MHC class I immunopeptidome by tapasin.Frontiers in immunology · 2025Article
- Mass Spectrometric Profiling of HLA-B44 Peptidomes Provides Evidence for Tapasin-Mediated Tryptophan Editing.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Mass spectrometric profiling of HLA-B44 peptidomes provides evidence for tapasin-mediated tryptophan editing.bioRxiv : the preprint server for biology · 2023Article
- HLA-C downregulation by HIV-1 adapts to host HLA genotype.PLoS pathogens · 2018Article
- Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity.eLife · 2018Article
- Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP).PLoS pathogens · 2018Article
- Article
- Distinct assembly profiles of HLA-B molecules.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- The principal genetic determinants for nasopharyngeal carcinoma in China involve the HLA class I antigen recognition groove.PLoS genetics · 2012Article
- Large-scale characterization of peptide-MHC binding landscapes with structural simulations.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Mutational analysis reveals a complex interplay of peptide binding and multiple biological features of HLA-B27.The Journal of biological chemistry · 2010Article
- Modes of calreticulin recruitment to the major histocompatibility complex class I assembly pathway.The Journal of biological chemistry · 2010Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Residue 116 of major histocompatibility complex (MHC) class I heavy chains is an important determinant of assembly, that can influence rates of ER-Golgi trafficking, binding to the transporter associated with antigen processing (TAP), tapasin dependence of assembly, and the efficiency and specificity of peptide binding. Here, we investigated assembly and peptide-binding differences between HLA-B*3501(S116) and HLA-B*3503(F116), two alleles differing only at position 116 of the MHC class I heavy chain, that are associated respectively with normal or rapid AIDS progression. A reduced intracellular maturation rate was observed for HLA-B*3503 in HIV-infected and uninfected cells, which correlated with enhanced binding of HLA-B*3503 to TAP. No significant differences in the intrinsic efficiency of in vitro peptide binding by HLA-B*3501 and HLA-B*3503 were measurable with several common peptides or peptide libraries, and both allotypes were relatively tapasin-independent for their assembly. However, thermostability differences between the two allotypes were measurable in a CD4(+) T cell line. These findings suggest that compared to HLA-B*3501, a reduced intracellular peptide repertoire for HLA-B*3503 could contribute to its slower intracellular trafficking and stronger association with rapid AIDS progression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.