ArticleModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc2010
Follicular lymphomas with plasmacytic differentiation include two subtypes.
Article in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- MNDA-positive Follicular Lymphoma is a heterogeneous disease: a case series study of 19 patients.Virchows Archiv : an international journal of pathology · 2026Article
- Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function.Blood advances · 2023Article
- Solitary follicular lymphoma with plasmacytic differentiation associated with localized AL amyloidosis in the jejunum.Annals of hematology · 2023Article
- Histopathologic, immunophenotypic, and mutational landscape of follicular lymphomas with plasmacytic differentiation.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Article
- The Diagnostic and Treatment Challenges of Concomitant Mantle Cell Lymphoma and IgM Myeloma.European journal of case reports in internal medicine · 2022Article
- The broad landscape of follicular lymphoma: Part I.Pathologica · 2020Review
- A case of AL amyloidosis associated with follicular lymphoma with plasmacytic differentiation.International journal of hematology · 2020Article
- Review
- Rare case report of an aggressive follicular lymphoid hyperplasia in maxilla.Oral and maxillofacial surgery · 2017Article
- Patient-derived xenografts of low-grade B-cell lymphomas demonstrate roles of the tumor microenvironment.Blood advances · 2017Article
- Marginal zone B-cell lymphoma mimicking extramedullary plasmacytoma and the clinical outcome after treatment.Archives of medical science : AMS · 2017Article
- The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.Virchows Archiv : an international journal of pathology · 2016Review
- The heterogeneity of follicular lymphomas: from early development to transformation.Virchows Archiv : an international journal of pathology · 2016Review
- Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Follicular lymphoma mimicking marginal zone lymphoma in lymph node: a case report.International journal of clinical and experimental pathology · 2014Article
- The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.Blood · 2011Review
- Molecular characteristics of mantle cell lymphoma presenting with clonal plasma cell component.The American journal of surgical pathology · 2011Article
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Abstract
Follicular lymphomas with plasmacytic differentiation were described more than two decades ago. However, the possibility that some of these reported cases are marginal zone lymphomas or composite lymphomas must be considered. In addition, it is also uncertain whether follicular lymphomas with plasmacytic differentiation have any unique cytogenetic or other features. Therefore, fluorescence immunophenotypic and interphase cytogenetic analysis of 14 well-characterized follicular lymphomas with plasmacytic differentiation was performed using a CD138 antibody to identify the plasma cells and with BCL2, BCL6, IGH@ and MALT1 break-apart probes and a chromosome 12 centromeric probe. CD10 was expressed in 12/14 cases, BCL6 in 12/12 cases and BCL2 in 12/14 cases. At least one cytogenetic abnormality was identified in 12/14 cases. The same abnormality was present in both the plasmacytic (CD138+) and non-plasmacytic (CD138-) component in all 10 evaluable cases. BCL2 rearrangements were present in seven cases (5 IGH@ rearranged, 1 IGH@-not rearranged, 1 IGH@-not evaluable), BCL6 rearrangement in two (1 also with BCL2/IGH@ rearrangement), +12 in 1, +MALT1 without +18 in 1, IGH@ rearrangement without other abnormalities in 1 and IGH@ rearranged or partially deleted in 1 case. No cases showed +BCL6 (3q27) or a MALT1 rearrangement. All six cases with an isolated BCL2 rearrangement had predominantly interfollicular plasmacytic cells whereas, 6/7 cases without the translocation had concentrations of intrafollicular or perifollicular plasmacytic cells (P<0.005), as did the case with BCL2 and BCL6 translocations. These results support the existence of bona fide follicular lymphomas with plasmacytic differentiation and support the clonal relationship of the neoplastic lymphoid and plasma cells in at least most of these cases. The differential distribution of the plasma cells, specifically in relation to the presence or absence of an isolated BCL2 rearrangement suggests that the latter cases may be distinctive, sharing some features with marginal zone lymphomas.
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