ArticleThe Journal of clinical endocrinology and metabolism2009
Activating autoantibodies against the calcium-sensing receptor detected in two patients with autoimmune polyendocrine syndrome type 1.
Article in The Journal of clinical endocrinology and metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Renal disorders in Autoimmune Polyendocrinopathy Candidiasis Ectodermal dystrophy (APECED): a systematic review.BMC pediatrics · 2025Pooled it
- Etiology and Pathophysiology of Hypoparathyroidism: A Narrative Review.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Pooled it
- Hypoparathyroidism induced by immune checkpoint inhibitors: a review of literature reports and real-world pharmacovigilance data.Endocrine connections · 2025Article
- Hypoparathyroidism: diagnosis, management and emerging therapies.Nature reviews. Endocrinology · 2025Review
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused by biased allosteric CaSR autoantibodies.JCI insight · 2022Article
- Novel Gene Mutations Regulating Immune Responses in Autoimmune Polyglandular Syndrome With an Atypical Course.Journal of the Endocrine Society · 2021Article
- Calcium-sensing receptor autoantibody-mediated hypoparathyroidism associated with immune checkpoint inhibitor therapy: diagnosis and long-term follow-up.Journal for immunotherapy of cancer · 2020Article
- Inflammation-induced hypoparathyroidism triggered by combination immune checkpoint blockade for melanoma.Journal for immunotherapy of cancer · 2019Article
- The calcium-sensing receptor in physiology and in calcitropic and noncalcitropic diseases.Nature reviews. Endocrinology · 2018Review
- Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).Antibodies (Basel, Switzerland) · 2017Review
- Molecular Basis of the Extracellular Ligands Mediated Signaling by the Calcium Sensing Receptor.Frontiers in physiology · 2016Review
- Early-onset hypoparathyroidism and chronic keratitis revealing APECED.Clinical case reports · 2015Article
- Hypoparathyroidism and central diabetes insipidus: in search of the link.European journal of pediatrics · 2014Article
- Calcium-sensing receptor 20 years later.American journal of physiology. Cell physiology · 2014Review
- Calcium-sensing receptor: Role in health and disease.Indian journal of endocrinology and metabolism · 2012Article
- New concepts in calcium-sensing receptor pharmacology and signalling.British journal of pharmacology · 2012Review
- APECED: is this a model for failure of T cell and B cell tolerance?Frontiers in immunology · 2012Article
- Hypoparathyroidism in the adult: epidemiology, diagnosis, pathophysiology, target-organ involvement, treatment, and challenges for future research.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Autoimmune hypocalciuric hypercalcemia unresponsive to glucocorticoid therapy in a patient with blocking autoantibodies against the calcium-sensing receptor.The Journal of clinical endocrinology and metabolism · 2011Article
- Physiology and pathophysiology of the calcium-sensing receptor in the kidney.American journal of physiology. Renal physiology · 2010Review
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6 authors at 3 institutions in 3 countries.
Funding
Abstract
contextAutoimmune polyendocrine syndrome type 1 (APS1) is an autosomal recessive disorder caused by mutations in the autoimmune regulator (AIRE) gene. Hypoparathyroidism occurs in 80% of patients with APS1 and has been suggested to result from an autoimmune reaction against the calcium-sensing receptor (CaSR) in parathyroid cells. Anti-CaSR binding antibodies have previously been detected in patients with APS1.
objectiveThe aim of this study was to determine whether anti-CaSR antibodies present in APS1 patients could modulate the response of the CaSR to stimulation by Ca(2+).
resultsThe results indicated that two of the 14 APS1 patients included in the study had anti-CaSR antibodies that stimulated the receptor. These antibodies were detected by their ability to increase both Ca(2+)-dependent extracellular signal-regulated kinase phosphorylation and inositol phosphate accumulation in human embryonic kidney 293 cells expressing the CaSR.
conclusionAn important implication of the present results is that although the majority of APS1 patients do not have CaSR-stimulating antibodies, there may be a small but substantial minority of patients in whom the hypoparathyroid state is the result of functional suppression of the parathyroid glands rather than their irreversible destruction.
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