ArticleProceedings of the National Academy of Sciences of the United States of America2009
Evolutionary maintenance of selfish homing endonuclease genes in the absence of horizontal transfer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Review
- Recurrent Modular Assembly Drives Independent Origins of Group II Introns Encoding LAGLIDADG Homing Endonucleases.Genome biology and evolution · 2026Article
- An Alternative Self-Splicing Intron Lifecycle Revealed by Dynamic Intron Turnover in Epichloë Endophyte Mitochondrial Genomes.Molecular biology and evolution · 2025Article
- Base-excision restriction enzymes: expanding the world of epigenetic immune systems.DNA research : an international journal for rapid publication of reports on genes and genomes · 2023Article
- Inteins in Science: Evolution to Application.Microorganisms · 2020Review
- Impact of a homing intein on recombination frequency and organismal fitness.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Flashy flagella: flagellin modification is relatively common and highly versatile among the Enterobacteriaceae.BMC genomics · 2016Article
- Intein Clustering Suggests Functional Importance in Different Domains of Life.Molecular biology and evolution · 2016Article
- Transcriptional response to copper excess and identification of genes involved in heavy metal tolerance in the extremophilic microalga Chlamydomonas acidophila.Extremophiles : life under extreme conditions · 2015Article
- Ancient Origin of the U2 Small Nuclear RNA Gene-Targeting Non-LTR Retrotransposons Utopia.PloS one · 2015Article
- Review
- High-throughput transcriptome sequencing and preliminary functional analysis in four Neotropical tree species.BMC genomics · 2014Article
- Inteins as indicators of gene flow in the halobacteria.Frontiers in microbiology · 2014Article
- A parasitic selfish gene that affects host promiscuity.Proceedings. Biological sciences · 2013Article
- Gene invasion in distant eukaryotic lineages: discovery of mutually exclusive genetic elements reveals marine biodiversity.The ISME journal · 2013Article
- Article
- A predictive model of intein insertion site for use in the engineering of molecular switches.PloS one · 2012Article
- Home and away- the evolutionary dynamics of homing endonucleases.BMC evolutionary biology · 2011Article
- Evolutionary dynamics of the mS952 intron: a novel mitochondrial group II intron encoding a LAGLIDADG homing endonuclease gene.Journal of molecular evolution · 2011Article
- IS-linked movement of a restriction-modification system.PloS one · 2011Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Homing endonuclease genes are "selfish" mobile genetic elements whose endonuclease promotes the spread of its own gene by creating a break at a specific target site and using the host machinery to repair the break by copying and inserting the gene at this site. Horizontal transfer across the boundary of a species or population within which mating takes place has been thought to be necessary for their evolutionary persistence. This is based on the assumption that they will become fixed in a host population, where opportunities of homing will disappear, and become susceptible to degeneration. To test this hypothesis, we modeled behavior of a homing endonuclease gene that moves during meiosis through double-strand break repair. We mathematically explored conditions for persistence of the homing endonuclease gene and elucidated their parameter dependence as phase diagrams. We found that, if the cost of the pseudogene is lower than that of the homing endonuclease gene, the 2 forms can persist in a population through autonomous periodic oscillation. If the cost of the pseudogene is higher, 2 types of dynamics appear that enable evolutionary persistence: bistability dependent on initial frequency or fixation irrespective of initial frequency. The prediction of long persistence in the absence of horizontal transfer was confirmed by stochastic simulations in finite populations. The average time to extinction of the endonuclease gene was found to be thousands of meiotic generations or more based on realistic parameter values. These results provide a solid theoretical basis for an understanding of these and other extremely selfish elements.
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