ArticleMolecular and cellular neurosciences2010
Regulated expression of the Ras effector Rin1 in forebrain neurons.
Article in Molecular and cellular neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- RIN1 regulates developmental and pain-related plasticity in spinal synapses via NMDA receptor subunit trafficking.PLoS biology · 2025Article
- Expression of RAS and RAB interactor 1 (RIN1) in head and neck tumors at selected hospital in Ghana.PloS one · 2024Article
- Change of Rin1 and Stathmin in the Animal Model of Traumatic Stresses.Frontiers in behavioral neuroscience · 2017Article
- Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- G proteins, p60TRP, and neurodegenerative diseases.Molecular neurobiology · 2013Review
- ABL fusion oncogene transformation and inhibitor sensitivity are mediated by the cellular regulator RIN1.Leukemia · 2011Article
- RIN1 inhibited TRPV1-dependent pain sensitization in a mouse model of bone cancer pain.Molecular painArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The Ras effector Rin1 is induced concomitant with synaptogenesis in forebrain neurons, where it inhibits fear conditioning and amygdala LTP. In epithelial cells, lower levels of Rin1 orchestrate receptor endocytosis. A 945 bp Rin1 promoter fragment was active in hippocampal neurons and directed accurate tissue-specific and temporal expression in transgenic mice. Regulated expression in neurons and epithelial cells was mediated in part by Snail transcriptional repressors: mutation of a conserved Snail site increased expression and endogenous Snai1 was detected at the Rin1 promoter. We also describe an element closely related to, but distinct from, the consensus site for REST, a master repressor of neuronal genes. Conversion to a consensus REST sequence reduced expression in both cell types. These results provide insight into regulated expression of a neuronal Ras effector, define a promoter useful in telencephalic neuron studies, and describe a novel REST site variant directing expression to mature neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.