ArticleNeurobiology of disease2010
Intact and injured endothelial cells differentially modulate postnatal murine forebrain neural stem cells.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 56 citations in OpenAlex.
- Universal method for the isolation of microvessels from frozen brain tissue: A proof-of-concept multiomic investigation of the neurovasculature.Brain, behavior, & immunity - health · 2023Article
- Telomerase reverse transcriptase promotes angiogenesis in neonatal rats after hypoxic-ischemic brain damage.PeerJ · 2022Article
- Angiogenin in the Neurogenic Subventricular Zone After Stroke.Frontiers in neurology · 2021Article
- Extrinsic Factors Driving Oligodendrocyte Lineage Cell Progression in CNS Development and Injury.Neurochemical research · 2020Review
- Molecular Mechanisms of Oligodendrocyte Regeneration in White Matter-Related Diseases.International journal of molecular sciences · 2018Review
- FACS isolation of endothelial cells and pericytes from mouse brain microregions.Nature protocols · 2018Article
- Neurovascular Alterations in Alzheimer's Disease: Transporter Expression Profiles and CNS Drug Access.The AAPS journal · 2017Review
- Oligodendrocyte Injury and Pathogenesis of HIV-1-Associated Neurocognitive Disorders.Brain sciences · 2016Review
- Heterocellular Contacts with Mouse Brain Endothelial CellsFrontiers in cellular neuroscience · 2016Article
- How Necessary is the Vasculature in the Life of Neural Stem and Progenitor Cells? Evidence from Evolution, Development and the Adult Nervous System.Frontiers in cellular neuroscience · 2016Article
- Gender-linked stem cell alterations in stroke and postpartum depression.CNS neuroscience & therapeutics · 2015Review
- Regional and stage-specific effects of prospectively purified vascular cells on the adult V-SVZ neural stem cell lineage.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- N-cadherin promotes recruitment and migration of neural progenitor cells from the SVZ neural stem cell niche into demyelinated lesions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Crosstalk between cerebral endothelium and oligodendrocyte.Cellular and molecular life sciences : CMLS · 2014Review
- Oligodendrogenesis in the normal and pathological central nervous system.Frontiers in neuroscience · 2014Review
- Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases.Frontiers in cellular neuroscience · 2013Review
- Exogenous and endogenous therapeutic effects of combination Sodium Ferulate and bone marrow stromal cells (BMSCs) treatment enhance neurogenesis after rat focal cerebral ischemia.Metabolic brain disease · 2013Article
- Two outward potassium current types are expressed during the neural differentiation of neural stem cells.Neural regeneration research · 2013Article
- Acute and chronic vascular responses to experimental focal arterial stroke in the neonate rat.Translational stroke research · 2013Article
- Proliferation and differentiation of neural stem cells co-cultured with cerebral microvascular endothelial cells after oxygen-glucose deprivation.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neural stem cells (NSCs) persist in the forebrain subventricular zone (SVZ) within a niche containing endothelial cells. Evidence suggests that endothelial cells stimulate NSC expansion and neurogenesis. Experimental stroke increases neurogenesis and angiogenesis, but how endothelial cells influence stroke-induced neurogenesis is unknown. We hypothesized intact or oxygen-glucose deprived (OGD) endothelial cells secrete factors that enhance neurogenesis. We co-cultured mouse SVZ neurospheres (NS) with endothelial cells, or differentiated NS in endothelial cell-conditioned medium (ECCM). NS also were expanded in ECCM from OGD-exposed (OGD-ECCM) endothelial cells to assess injury effects. ECCM significantly increased NS production. NS co-cultured with endothelial cells or ECCM generated more immature-appearing neurons and oligodendrocytes, and astrocytes with radial glial-like/reactive morphology than controls. OGD-ECCM stimulated neuroblast migration and yielded neurons with longer processes and more branching. These data indicate that intact and injured endothelial cells exert differing effects on NSCs, and suggest targets for stimulating regeneration after brain insults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.