ArticleJournal of neuroscience methods2010
A novel method for modeling facial allodynia associated with migraine in awake and freely moving rats.
Article in Journal of neuroscience methods, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 65 citations in OpenAlex.
- From bench to bedside: relevant animal models across the migraine attack phases.The journal of headache and pain · 2026Review
- Animal Models of Chronic Migraine: From the Bench to Therapy.Current pain and headache reports · 2024Review
- Hangover headache and its behavioral changes in rats.Iranian journal of basic medical sciences · 2023Article
- Estradiol Treatment Enhances Behavioral and Molecular Changes Induced by Repetitive Trigeminal Activation in a Rat Model of Migraine.Biomedicines · 2022Article
- Neurogenic Inflammation: The Participant in Migraine and Recent Advancements in Translational Research.Biomedicines · 2021Review
- Interleukin-6 induces spatially dependent whole-body hypersensitivity in rats: implications for extracephalic hypersensitivity in migraine.The journal of headache and pain · 2021Article
- Voluntary Wheel Running Partially Attenuates Early Life Stress-Induced Neuroimmune Measures in the Dura and Evoked Migraine-Like Behaviors in Female Mice.Frontiers in physiology · 2021Article
- Trigeminal activation patterns evoked by chemical stimulation of the dura mater in rats.The journal of headache and pain · 2020Article
- Assessing complex movement behaviors in rodent models of neurological disorders.Neurobiology of learning and memory · 2019Article
- Modulation of brain networks by sumatriptan-naproxen in the inflammatory soup migraine model.Pain · 2019Article
- Animal models of migraine and experimental techniques used to examine trigeminal sensory processing.The journal of headache and pain · 2019Review
- The influence of rapid eye movement sleep deprivation on nociceptive transmission and the duration of facial allodynia in rats: a behavioral and Fos immunohistochemical study.The journal of headache and pain · 2019Article
- Behavioral and cognitive animal models in headache research.The journal of headache and pain · 2019Review
- Non-invasive dural stimulation in mice: A novel preclinical model of migraine.Cephalalgia : an international journal of headache · 2019Article
- Region-specific disruption of the blood-brain barrier following repeated inflammatory dural stimulation in a rat model of chronic trigeminal allodynia.Cephalalgia : an international journal of headache · 2018Article
- Functional interactions between transient receptor potential M8 and transient receptor potential V1 in the trigeminal system: Relevance to migraine pathophysiology.Cephalalgia : an international journal of headache · 2018Article
- Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions.Frontiers in cellular neuroscience · 2018Review
- Cranial dural permeability of inflammatory nociceptive mediators: Potential implications for animal models of migraine.Cephalalgia : an international journal of headache · 2017Article
- Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache.Scientific reports · 2017Article
- Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.Brain research · 2017Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Migraine is a neurovascular disorder that induces debilitating headaches associated with multiple symptoms including facial allodynia, characterized by heightened responsivity to normally innocuous mechanical stimuli. It is now well accepted that immune activation and immune-derived inflammatory mediators enhance pain responsivity, including the trigeminal system. Nociceptive ("pain" responsive) trigeminal nerves densely innervate the cranial meninges. We have recently proposed that the meninges may serve as a previously unidentified, key interface between the peripheral immune system and the CNS with potential implications for understanding underlying migraine mechanisms. Our focus here is the development of a model for facial allodynia associated with migraine. We developed a model wherein an indwelling catheter is placed between the skull and dura, allowing immunogenic stimuli to be administered over the dura in awake and freely moving rats. Since the catheter does not contact the brain itself, any proinflammatory cytokines induced following manipulation derive from resident or recruited meningeal immune cells. While surgery alone does not alter immune activation markers, TNF or IL6 mRNA and/or protein, it does decrease gene expression and increase protein expression of IL-1 at 4 days after surgery. Using this model we show the induction of facial allodynia in response to supradural administration of either the HIV glycoprotein gp120 or inflammatory soup (bradykinin, histamine, serotonin, and prostaglandin E2), and the induction of hindpaw allodynia in our model after inflammatory soup. This model allows time- and dose-dependent assessment of the relationship between changes in meningeal inflammation and corresponding exaggerated pain behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.