ArticleExperimental cell research2010
Identification of tubby and tubby-like protein 1 as eat-me signals by phage display.
Article in Experimental cell research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 44 citations in OpenAlex.
- Article
- Peptide discovery across the spectrum of neuroinflammation; microglia and astrocyte phenotypical targeting, mediation, and mechanistic understanding.Frontiers in molecular neuroscience · 2024Review
- Efferocytosis of vascular cells in cardiovascular disease.Pharmacology & therapeutics · 2022Review
- The Phagocytic Code Regulating Phagocytosis of Mammalian Cells.Frontiers in immunology · 2021Review
- Comparative Ligandomic Analysis of Human Lung Epithelial Cells Exposed to PMBiomedical and environmental sciences : BES · 2020Article
- Distinct mutations with different inheritance mode caused similar retinal dystrophies in one family: a demonstration of the importance of genetic annotations in complicated pedigrees.Journal of translational medicine · 2018Article
- Maternal uniparental isodisomy of chromosome 6 unmasks a novel variant inMolecular vision · 2018Article
- Tubby-like protein 1 (Tulp1) is a target of microRNA-134 and is down-regulated in experimental epilepsy.International journal of physiology, pathophysiology and pharmacology · 2017Article
- Ligand Activation of TAM Family Receptors-Implications for Tumor Biology and Therapeutic Response.Cancers · 2016Review
- Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells.Cell biology and toxicology · 2016Article
- The regulatory role of hepatoma-derived growth factor as an angiogenic factor in the eye.Molecular vision · 2016Article
- Lyar Is a New Ligand for Retinal Pigment Epithelial Phagocytosis.Journal of cellular biochemistry · 2015Article
- ABCF1 extrinsically regulates retinal pigment epithelial cell phagocytosis.Molecular biology of the cell · 2015Article
- Who let the dogs out?: detrimental role of Galectin-3 in hypoperfusion-induced retinal degeneration.Journal of neuroinflammation · 2015Article
- Article
- Axl phosphorylates Elmo scaffold proteins to promote Rac activation and cell invasion.Molecular and cellular biology · 2015Article
- Reticulocalbin-1 facilitates microglial phagocytosis.PloS one · 2015Article
- Axl as a mediator of cellular growth and survival.Oncotarget · 2014Review
- TAM receptor tyrosine kinases: expression, disease and oncogenesis in the central nervous system.Brain research · 2014Review
- Interaction analysis through proteomic phage display.BioMed research international · 2014Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Phagocytosis is an important process for the removal of apoptotic cells or cellular debris. Eat-me signals control the initiation of phagocytosis and hold the key for in-depth understanding of its molecular mechanisms. However, because of difficulties to identify unknown eat-me signals, only a limited number of them have been identified and characterized. Using a newly developed functional cloning strategy of open reading frame (ORF) phage display, we identified nine putative eat-me signals, including tubby-like protein 1 (Tulp1). This further led to the elucidation of tubby as the second eat-me signal in the same protein family. Both proteins stimulated phagocytosis of retinal pigment epithelium (RPE) cells and macrophages. Tubby-conjugated fluorescent microbeads facilitated RPE phagocytosis. Tubby and Tulp1, but not other family members, enhanced the uptake of membrane vesicles by RPE cells in synergy. Retinal membrane vesicles of Tubby mice and Tulp1(-/-) mice showed reduced activities for RPE phagocytosis, which were compensated by purified tubby and Tulp1, respectively. These data reveal a novel activity of tubby and Tulp1, and demonstrate that unbiased identification of eat-me signals by the broadly applicable strategy of ORF phage display can provide detailed insights into phagocyte biology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.