Evidence map›Paper›PMID 19837059›Full record

ReviewEuropean journal of pharmacology2009

Immunotherapy of cancer.

Hossein Borghaei, Mitchell R Smith, Kerry S Campbell

Abstract readReview
In one paragraph

Review in European journal of pharmacology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
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  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Therapeutic Fusion Proteins.The AAPS journal · 2023
    Review
  14. Review
  15. Nanocarriers for cancer nano-immunotherapy.Drug delivery and translational research · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Neurology of cancer immunotherapy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Hossein BorghaeiDepartment of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. hossein.borghaei@fccc.edu
Mitchell R Smith
Kerry S Campbell

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Margaret von Mehren · 1985 to 2026
$138.8M
Negative Signalling by Killer Ig-like ReceptorsR01CA083859 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CAMPBELL, KERRY S · 2000 to 2014
$3.8M
Mechanisms of NK Cell Activation by the KIR2DL4 ReceptorR01CA100226 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CAMPBELL, KERRY S · 2004 to 2008
$1.4M
Mechanisms of NK Cell Activation by the KIR2DL4 ReceptorR56CA100226 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI CAMPBELL, KERRY S · 2009 to 2009
$279k
NCI NIH HHS CA06927NCI NIH HHS CA083859NCI NIH HHS CA100226NCI NIH HHS P30 CA006927NCI NIH HHS R01 CA083859NCI NIH HHS R01 CA100226NCI NIH HHS R56 CA100226
6 · The paper itself

Abstract

Major advances have been made in the field of immunology in the past two decades. A better understanding of the molecular and cellular mechanisms controlling the immune system has opened the door to many innovative and promising new cancer therapies that manipulate the immune response. For instance, toll-like receptor agonists have been shown to boost immune responses toward tumors. Also, a wide array of cell-based immunotherapies utilizing T cells, NK cells, and dendritic cells have been established. Furthermore, a rapidly expanding repertoire of monoclonal antibodies is being developed to treat tumors, and many of the available antibodies have demonstrated impressive clinical responses. Here, we examine some of these immunotherapeutic approaches currently in use or testing to treat cancer, and we examine available evidence with regards to mechanism and efficacy of these treatments.

Indexed as

AnimalsAntibodies, MonoclonalDendritic CellsHumansImmunotherapyKiller Cells, NaturalNeoplasmsRadioimmunotherapyT-LymphocytesToll-Like ReceptorsAntibodies, MonoclonalToll-Like Receptors

Identifiers

PMID19837059
PMCPMC2783916

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.