ArticleCell2009
A neural circuit mechanism integrating motivational state with memory expression in Drosophila.
Article in Cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 298 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
298 citing papers in PubMed, 619 citations in OpenAlex.
- Article
- Cellular source and circuit context organize functional specificity in thebioRxiv : the preprint server for biology · 2026Article
- Creating true and false memories from forgotten information in Drosophila.Nature neuroscience · 2026Article
- Cell-type-resolved RNA-seq reveals molecular signatures of sexual experience inNAR genomics and bioinformatics · 2026Article
- Hunger states modulate aggression via opposing dopamine pathways.Nature communications · 2026Article
- Article
- Identification of Neuropeptide F (NPF) Signaling and Associated Regulation of Food Intake in the Dark Black Chafer BeetleBiology · 2026Article
- Systematic analysis of mushroom body-innervating dopaminergic neuron activity in different physiological states in Drosophila.Biomedical journal · 2026Article
- Conserved dopaminergic system in Octopus minor: molecular characterization and spatial expression.Brain structure & function · 2026Article
- A signaling hub in the mosquito rectum coordinates reproductive investment after blood feeding.Current biology : CB · 2026Article
- A pair of interneurons that confer positive real-time valence to sweet sensation in Drosophila.Current biology : CB · 2026Article
- Re-exposure to reward re-evaluates related memories.Current biology : CB · 2026Article
- Hungry for Knowledge: Octopamine Signaling Regulates Hunger-Enhanced Olfactory Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Starve-Feed Cycles Direct Quiescence to Proliferation Transitions inbioRxiv : the preprint server for biology · 2026Article
- Neuropeptide F-expressing neurons in Drosophila constitute centrifugal pathway to optic lobes.PloS one · 2026Article
- Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons inNeuroscience insights · 2026Article
- Insect neuropeptides as agents for pest control: potential and challenges.Biological research · 2025Review
- Shaping of olfactory responses by taste in a new assay for operant learning in Drosophila melanogaster.The Journal of experimental biology · 2025Article
- Hunger modulates exploration through suppression of dopamine signaling in the tail of the striatum.Neuron · 2025Article
- Phenomenal interface theory: a model for basal consciousness.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
238 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.