Evidence map›Paper›PMID 19837030›Full record

ReviewCell2009

Phototransduction motifs and variations.

King-Wai Yau, Roger C Hardie

Open access · bronzeAbstract readReview
In one paragraph

Review in Cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 247 papers.

0numbers the graph read from it
0cells of the map it votes in
247citing papers in PubMed
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

247 citing papers in PubMed, 481 citations in OpenAlex.

  1. Article
  2. Article
  3. Neuromorphic Devices and Computing for Sensing, Memory, and Control.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. E122Q rhodopsin: pigment microspectrophotometry, photoreceptor light responses, and bleaching adaptation.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Article
  5. Article
  6. Review
  7. Retina-Inspired Bi-Based Terahertz Photonic Neuromorphic Devices.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. The physiology of dark adaptation: Progress and future directions.Progress in retinal and eye research · 2025
    Review
  18. Design principles of ciliary signaling.Journal of cell science · 2025
    Review
  19. Review
  20. Review

187 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

King-Wai YauSolomon H. Snyder Department of Neuroscience and Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. kwyau@mail.jhmi.edu
Roger C Hardie
Johns Hopkins University · USUniversity of Cambridge · GB

Funding

Retinal melanopsin pathway: Signaling &ConnectivityR01EY014596 · NEI · JOHNS HOPKINS UNIVERSITY · PI KING-WAI YAU · 2003 to 2026
$11.9M
VISUAL TRANSDUCTION IN RETINAL PHOTORECEPTORSR01EY006837 · NEI · JOHNS HOPKINS UNIVERSITY · PI KING-WAI YAU · 1987 to 2026
$8.5M
Transduction mechanism in olfactory sensory neuronsR01DC006904 · NIDCD · JOHNS HOPKINS UNIVERSITY · PI YAU, KING-WAI · 2004 to 2013
$3.5M
Biotechnology and Biological Sciences Research Council BB/D007585/1Biotechnology and Biological Sciences Research Council BB/G006865/1NEI NIH HHS R01 EY006837NEI NIH HHS R01 EY014596NIDCD NIH HHS R01 DC006904
6 · The paper itself

Abstract

Seeing begins in the photoreceptors, where light is absorbed and signaled to the nervous system. Throughout the animal kingdom, photoreceptors are diverse in design and purpose. Nonetheless, phototransduction-the mechanism by which absorbed photons are converted into an electrical response-is highly conserved and based almost exclusively on a single class of photoproteins, the opsins. In this Review, we survey the G protein-coupled signaling cascades downstream from opsins in photoreceptors across vertebrate and invertebrate species, noting their similarities as well as differences.

Indexed as

Light Signal TransductionAnimalsHumansPhotoreceptor Cells, InvertebratePhotoreceptor Cells, VertebrateReceptors, G-Protein-CoupledReceptors, G-Protein-Coupled

Identifiers

PMID19837030
PMCPMC2885920
OpenAlexW2151900188

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.