ReviewTrends in endocrinology and metabolism: TEM2010
Lysophosphatidic acid (LPA) signaling in vertebrate reproduction.
Review in Trends in endocrinology and metabolism: TEM, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed.
- Neuropeptides NLP-10 and FLP-18 stimulate lipid catabolism in chronically diet-restrictedbioRxiv : the preprint server for biology · 2026Article
- Metabolome analysis as a potential source of endometriosis biomarkers with the use of multiomics approach in its diagnosis.Scientific reports · 2025Article
- Phosphatidic acid induces cytoskeletal rearrangements through the Src-FAK-RhoA/ROCK signaling pathway during decidualization.The FEBS journal · 2025Article
- Evaluation of Lysophosphatidic Acid Effects and Its Receptors During Bovine Embryo Development.International journal of molecular sciences · 2025Article
- Lysophosphatidic acid promotes endometrial decidualization in recurrent implantation failure patients by regulating LPAR6.Frontiers in cell and developmental biology · 2025Article
- Genome-wide association studies and functional annotation of pre-weaning calf mortality and reproductive traits in Nellore cattle from experimental selection lines.BMC genomics · 2024Article
- Metabolomics-based study of the effect of dietary N-carbamoylglutamic acid addition to heifers in late pregnancy on newborn calves.Frontiers in veterinary science · 2024Article
- Expression of lysophosphatidic acid receptors in the rat uterus: cellular distribution of protein and gestation-associated changes in gene expression.The Journal of veterinary medical science · 2023Article
- COVID-19 Infection during Pregnancy: Disruptions in Lipid Metabolism and Implications for Newborn Health.International journal of molecular sciences · 2023Article
- Lysophosphatidic acid stimulates rat uterine contraction in vitro.The Journal of reproduction and development · 2023Article
- Transplantation-based screen identifies inducers of muscle progenitor cell engraftment across vertebrate species.Cell reports · 2023Article
- Role of functional fatty acids in modulation of reproductive potential in livestock.Journal of animal science and biotechnology · 2023Review
- GPR35 acts a dual role and therapeutic target in inflammation.Frontiers in immunology · 2023Review
- Rumen-protected methionine supplementation alters lipid profile of preimplantation embryo and endometrial tissue of Holstein cows.Frontiers in veterinary science · 2023Article
- Past COVID-19: The Impact on IVF Outcomes Based on Follicular Fluid Lipid Profile.International journal of molecular sciences · 2022Article
- Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development.Communications biology · 2022Article
- Lysophosphatidic Acid Improves Human Sperm Motility by Enhancing Glycolysis and Activating L-Type Calcium Channels.Frontiers in endocrinology · 2022Article
- Insight on Polyunsaturated Fatty Acids in Endometrial Receptivity.Biomolecules · 2021Review
- Platelet-activating factor acetyl hydrolase IB2 dysregulated cell proliferation in ovarian cancer.Cancer cell international · 2021Article
- Sperm Lipid Markers of Male Fertility in Mammals.International journal of molecular sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Lysophosphatidic acid (LPA) is a cell membrane phospholipid metabolite that can act as an extracellular signal. Its effects are mediated through at least five G protein-coupled receptors, LPA(1-5), and probably others as well. Studies in multiple species including LPAR-deficient mice and humans have identified or implicated important roles for receptor-mediated LPA signaling in multiple aspects of vertebrate reproduction. These include ovarian function, spermatogenesis, fertilization, early embryo development, embryo implantation, embryo spacing, decidualization, pregnancy maintenance and parturition. LPA signaling can also have pathological consequences, influencing aspects of endometriosis and ovarian cancer. Here we review recent progress in LPA signaling research relevant to female and male reproduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.