ArticleEuropean journal of medicinal chemistry2010
Discovery of colon tumor cell growth inhibitory agents through a combinatorial approach.
Article in European journal of medicinal chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
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- Discovery of Novel 3-Cyanopyridines as Survivin Modulators and Apoptosis Inducers.Molecules (Basel, Switzerland) · 2020Article
- Synthesis of Biologically Active Molecules through Multicomponent Reactions.Molecules (Basel, Switzerland) · 2020Review
- Click-Engineered, Bioresponsive, and Versatile Particle-Protein-Dye System.ACS applied bio materials · 2019Article
- Structures, photoresponse properties and DNA binding abilities of 4-(4-pyridinyl)-2-pyridone salts.RSC advances · 2019Article
- PIM1: a promising target in patients with triple-negative breast cancer.Medical oncology (Northwood, London, England) · 2017Review
- Sequestering survivin to functionalized nanoparticles: a strategy to enhance apoptosis in cancer cells.Biomaterials science · 2016Article
- Synthesis and biological evaluation of 2-oxonicotinonitriles and 2-oxonicotinonitrile based nucleoside analogues.European journal of medicinal chemistry · 2014Article
- Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity.European journal of medicinal chemistry · 2013Article
- Modulating the cyclic guanosine monophosphate substrate selectivity of the phosphodiesterase 3 inhibitors by pyridine, pyrido[2,3-d]pyrimidine derivatives and their effects upon the growth of HT-29 cancer cell line.Chemical & pharmaceutical bulletin · 2013Article
- Novel Therapeutics: NSAIDs, Derivatives, and Phosphodiesterases.Current colorectal cancer reports · 2012Article
- CoMFA and CoMSIA studies of 1,2-dihydropyridine derivatives as anticancer agents.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2012Article
- Four-component synthesis of 1,2-dihydropyridine derivatives and their evaluation as anticancer agents.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2012Article
- Plant ubiquitin-proteasome pathway and its role in gibberellin signaling.Cell research · 2011Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Two series with the general formula of 4,6-diaryl-2-oxo-1,2 dihydropyridine-3-carbonitriles and their isosteric 4,6-diaryl-2-imino-1,2-dihydropyridine-3-carbonitrile were synthesized through one pot reaction of the appropriate acetophenone, aldehyde, ammonium acetate with ethyl cyanoacetate or malononitrile, respectively. The synthesized compounds were evaluated for their tumor cell growth inhibitory activity against the human HT-29 colon tumor cell line, as well as their PDE3 inhibitory activity. Compound 4-(2-Ethoxyphenyl)-2-oxo-6-thiophen-3-yl-1,2-dihydropyridine-3 carbonitrile (21) showed tumor cell growth inhibitory activity with an IC50 value of 1.25 microM. Meanwhile, 4-(4-Ethoxyphenyl)-2-imino-6-(thiophen-3-yl)-1,2-dihydropyridine-3-carbonitrile (26) showed inhibitory effect upon PDE3 using cAMP or cGMP as substrate. No correlation exists between PDE3 inhibition and the tumor cell growth inhibitory activity. Docking compound 21 to other possible molecular targets showed the potential to bind PIM1 Kinase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.