ReviewFrontiers in neuroendocrinology2010
Leptin and the systems neuroscience of meal size control.
Review in Frontiers in neuroendocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.
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Who cites it
71 citing papers in PubMed.
- NTS Neural Subtypes and Satiety Pathways: taVNS as a Novel Neuromodulatory Intervention.Brain sciences · 2026Review
- Development of Insulin and Leptin Resistance in the Mouse Brainstem with Age.Molecular neurobiology · 2026Article
- Article
- Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice.Endocrinology · 2025Article
- AgRP neurons mediate activity-dependent development of oxytocin connectivity and autonomic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- APOE4 rat model of Alzheimer's disease: sex differences, genetic risk and diet.BMC neuroscience · 2024Article
- Elevated interleukin-6 in women with binge-eating spectrum disorders.The International journal of eating disorders · 2024Article
- CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Neuropeptides Modulate Feeding via the Dopamine Reward Pathway.Neurochemical research · 2023Review
- Paraventricular nucleus-Medullary interactions: How they help enable endocrine responses to metabolic stress.Current opinion in endocrine and metabolic research · 2022Article
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity.Nature communications · 2021Article
- Good taste or gut feeling? A new method in rats shows oro-sensory stimulation and gastric distention generate distinct and overlapping brain activation patterns.The International journal of eating disorders · 2021Article
- Unraveling the Role of Leptin in Liver Function and Its Relationship with Liver Diseases.International journal of molecular sciences · 2020Review
- Loss of CTRP4 alters adiposity and food intake behaviors in obese mice.American journal of physiology. Endocrinology and metabolism · 2020Article
- Leptin suppresses development of GLP-1 inputs to the paraventricular nucleus of the hypothalamus.eLife · 2020Article
- Role of SOCS3 in POMC neurons in metabolic and cardiovascular regulation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Limbic control over the homeostatic need for sodium.Scientific reports · 2019Article
- Estradiol and the control of feeding behavior.Steroids · 2018Review
- Endogenous Glucagon-like Peptide-1 Receptor Signaling in the Nucleus Tractus Solitarius is Required for Food Intake Control.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
11 more citing papers are in PubMed but not listed here.
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Authors and funding
1 author.
Funding
Abstract
The development of effective pharmacotherapy for obesity will benefit from a more complete understanding of the neural pathways and the neurochemical signals whose actions result in the reduction of the size of meals. This review examines the neural control of meal size and the integration of two principal sources of that control--satiation signals arising from the gastrointestinal tract and CNS leptin signaling. Four types of integrations that are central to the control of meal size are described and each involves the neurons of the nucleus tractus solitarius (NTS) in the dorsal hindbrain. Data discussed show that NTS neurons integrate information arising from: (1) ascending GI-derived vagal afferent projections, (2) descending neuropeptidergic projections from leptin-activated arcuate and paraventricular nucleus neurons, (3) leptin signaling in NTS neurons themselves and (4) melanocortinergic projections from NTS and hypothalamic POMC neurons to NTS neurons and melanocortinergic modulation of vagal afferent nerve terminals that are presynaptic to NTS neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.