ArticleHearing research2010
Measurement of conductive hearing loss in mice.
Article in Hearing research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- TUBB4B is essential for the cytoskeletal architecture of cochlear supporting cells and motile cilia development.Communications biology · 2024Article
- Stimulus-frequency otoacoustic emissions and middle-ear pressure gains in a finite-element mouse model.The Journal of the Acoustical Society of America · 2022Article
- Audiologic characterization using clinical physiological measures: Normative data from macaque monkeys.Hearing research · 2022Article
- Evaluation of acoustic changes in and the healing outcomes of rat eardrums with pars tensa and pars flaccida perforations.Laryngoscope investigative otolaryngology · 2022Article
- Role of a novel mouse mutant of theFrontiers in neurology · 2022Article
- Hearing impairment in murine model of Down syndrome.Frontiers in genetics · 2022Article
- Conductive Hearing Loss in the Hyp Mouse Model of X-Linked Hypophosphatemia Is Accompanied by Hypomineralization of the Auditory Ossicles.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Assessment of auditory and vestibular damage in a mouse model after single and triple blast exposures.Hearing research · 2021Article
- Cochlin Deficiency Protects Against Noise-Induced Hearing Loss.Frontiers in molecular neuroscience · 2021Article
- Distortion product otoacoustic emissions: Sensitive measures of tympanic -membrane perforation and healing processes in a gerbil model.Hearing research · 2019Article
- The adhesion molecule cadherin 11 is essential for acquisition of normal hearing ability through middle ear development in the mouse.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Intracochlear Pressures in Simulated Otitis Media With Effusion: A Temporal Bone Study.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2018Article
- GC-B Deficient Mice With Axon Bifurcation Loss Exhibit Compromised Auditory Processing.Frontiers in neural circuits · 2018Article
- Functional Outcomes of Heparin-Binding Epidermal Growth Factor-Like Growth Factor for Regeneration of Chronic Tympanic Membrane Perforations in Mice.Tissue engineering. Part A · 2017Article
- Therapeutic value of nerve growth factor in promoting neural stem cell survival and differentiation and protecting against neuronal hearing loss.Molecular and cellular biochemistry · 2017Article
- Identification of induced and naturally occurring conductive hearing loss in mice using bone conduction.Hearing research · 2017Article
- Morin hydrate promotes inner ear neural stem cell survival and differentiation and protects cochlea against neuronal hearing loss.Journal of cellular and molecular medicine · 2017Article
- Dissection of the Auditory Bulla in Postnatal Mice: Isolation of the Middle Ear Bones and Histological Analysis.Journal of visualized experiments : JoVE · 2017Article
- Mechanical damage of tympanic membrane in relation to impulse pressure waveform - A study in chinchillas.Hearing research · 2016Article
- Hearing Loss after Round Window Surgery in Mice Is due to Middle Ear Effusion.Audiology & neuro-otology · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
In order to discriminate conductive hearing loss from sensorineural impairment, quantitative measurements were used to evaluate the effect of artificial conductive pathology on distortion-product otoacoustic emissions (DPOAEs), auditory brainstem responses (ABRs) and laser-Doppler vibrometry (LDV) in mice. The conductive manipulations were created by perforating the pars flaccida of the tympanic membrane, filling or partially filling the middle-ear cavity with saline, fixing the ossicular chain, and interrupting the incudo-stapedial joint. In the saline-filled and ossicular-fixation groups, averaged DPOAE thresholds increased relative to the control state by 20-36 and 25-39 dB, respectively with the largest threshold shifts occurring at frequencies less than 20kHz, while averaged ABR thresholds increased 12-19 and 12-25 dB, respectively without the predominant low-frequency effect. Both DPOAE and ABR thresholds were elevated by less than 10 dB in the half-filled saline condition; no significant change was observed after pars flaccida perforation. Conductive pathology generally produced a change in DPOAE threshold in dB that was 1.5-2.5 times larger than the ABR threshold change at frequencies less than 30 kHz; the changes in the two thresholds were nearly equal at the highest frequencies. While mild conductive pathology (ABR threshold shifts of <10 dB) produced parallel shifts in DPOAE growth with level functions, manipulations that produced larger conductive hearing losses (ABR threshold shifts >10 dB) were associated with significant deceases in DPOAE growth rate. Our LDV measurements are consistent with others and suggest that measurements of umbo velocity are not an accurate indicator of conductive hearing loss produced by ossicular lesions in mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.