Evidence map›Paper›PMID 19835637›Full record

ArticleJournal of biology2009

Molecular machines or pleiomorphic ensembles: signaling complexes revisited.

Bruce J Mayer, Michael L Blinov, Leslie M Loew

Abstract read
In one paragraph

Article in Journal of biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Phase separation and molecular ordering of the prion-like domain of the Arabidopsis thermosensory protein EARLY FLOWERING 3.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. The role of ordered cooperative assembly in biomolecular condensates.Nature reviews. Molecular cell biology · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Combinatorial protein-protein interactions on a polymerizing scaffold.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bruce J MayerRichard D Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-3301, USA. bmayer@neuron.uchc.edu
Michael L Blinov
Leslie M Loew

Funding

VIRTUAL FCSP41RR013186 · NCRR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI SABATINI, BERNARDO L · 1998 to 2011
$14.2M
POLARITY IN NETWORKS AND PATHWAYS(RMI)U54RR022232 · NCRR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LOEW, LESLIE M · 2005 to 2009
$12.9M
Functional Role of NCK and CRK Binding InteractionsR01CA082258 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MAYER, BRUCE J. · 1999 to 2012
$4.2M
COMPUTATIONAL TOOLS FOR RULE-BASED MODELING OF BIOCHEMICAL SYSTEMSR01GM076570 · NIGMS · UNIVERSITY OF NEW MEXICO · PI HLAVACEK, WILLIAM S · 2007 to 2009
$815k
NCI NIH HHS R01 CA082258NCI NIH HHS R01CA82258NCRR NIH HHS P41 RR013186NCRR NIH HHS P41RR013186NCRR NIH HHS U54 RR022232NCRR NIH HHS U54RR022232NIGMS NIH HHS R01 GM076570NIGMS NIH HHS R01GM076570
6 · The paper itself

Abstract

Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by misdirecting us away from investigating critical issues.

Indexed as

Adaptor Proteins, Signal TransducingAlgorithmsBinding SitesComputational BiologyComputer SimulationModels, MolecularModels, StatisticalNucleic Acid ConformationPhosphorylationProtein BindingProtein ConformationProtein FoldingSignal TransductionThermodynamicsAdaptor Proteins, Signal Transducing

Identifiers

PMID19835637
PMCPMC2776906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.