ArticleNutrition & metabolism2009
Different responsiveness to a high-fat/cholesterol diet in two inbred mice and underlying genetic factors: a whole genome microarray analysis.
Article in Nutrition & metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice.Molecular metabolism · 2025Article
- Gut-Liver Axis-Mediated Anti-Obesity Effects and Viscosity Characterization of a Homogenized Viscous Vegetable Mixture in Mice Fed a High-Fat Diet.Plants (Basel, Switzerland) · 2025Article
- Association of dietary quality indicators with gallstones in the US: NHANES 2017-2020.BMC public health · 2025Article
- Coronary Microvascular Dysfunction Is Associated With Augmented Lysosomal Signaling in Hypercholesterolemic Mice.Journal of the American Heart Association · 2024Article
- Coronary Microvascular Dysfunction is Associated with Augmented Lysosomal Signaling in Hypercholesterolemic Mice.bioRxiv : the preprint server for biology · 2024Article
- Assessment of mitochondrial function in metabolic dysfunction-associated fatty liver disease using obese mouse models.Zoological research · 2020Article
- Analysis of diet-induced differential methylation, expression, and interactions of lncRNA and protein-coding genes in mouse liver.Scientific reports · 2018Article
- Differential organ phenotypes after postnatal Igf1r gene conditional deletion induced by tamoxifen in UBC-CreERT2; Igf1r fl/fl double transgenic mice.Transgenic research · 2015Article
- Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet.Toxicology and applied pharmacology · 2012Article
- Selective breeding of mice for different susceptibilities to high fat diet-induced glucose intolerance: Development of two novel mouse lines, Selectively bred Diet-induced Glucose intolerance-Prone and -Resistant.Journal of diabetes investigation · 2012Article
- Inflammatory Signals shift from adipose to liver during high fat feeding and influence the development of steatohepatitis in mice.Journal of inflammation (London, England) · 2011Article
- Loss of intestinal GATA4 prevents diet-induced obesity and promotes insulin sensitivity in mice.American journal of physiology. Endocrinology and metabolism · 2011Article
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Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo investigate different responses to a high-fat/cholesterol diet and uncover their underlying genetic factors between C57BL/6J (B6) and DBA/2J (D2) inbred mice.
methodsB6 and D2 mice were fed a high-fat/cholesterol diet for a series of time-points. Serum and bile lipid profiles, bile acid yields, hepatic apoptosis, gallstones and atherosclerosis formation were measured. Furthermore, a whole genome microarray was performed to screen hepatic genes expression profile. Quantitative real-time PCR, western blot and TUNEL assay were conducted to validate microarray data.
resultsAfter fed the high-fat/cholesterol diet, serum and bile total cholesterol, serum cholesterol esters, HDL cholesterol and Non-HDL cholesterol levels were altered in B6 but not significantly changed in D2; meanwhile, biliary bile acid was decreased in B6 but increased in D2. At the same time, hepatic apoptosis, gallstones and atherosclerotic lesions occurred in B6 but not in D2. The hepatic microarray analysis revealed distinctly different genes expression patterns between B6 and D2 mice. Their functional pathway groups included lipid metabolism, oxidative stress, immune/inflammation response and apoptosis. Quantitative real time PCR, TUNEL assay and western-blot results were consistent with microarray analysis.
conclusionDifferent genes expression patterns between B6 and D2 mice might provide a genetic basis for their distinctive responses to a high-fat/cholesterol diet, and give us an opportunity to identify novel pharmaceutical targets in related diseases in the future.
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Registered trials
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