ArticleDigestive diseases and sciences2010
Bacterial translocation to mesenteric lymph nodes increases in chronic portal hypertensive rats.
Article in Digestive diseases and sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity.Biology · 2024Article
- Short-Chain Fatty Acids in Gut-Heart Axis: Their Role in the Pathology of Heart Failure.Journal of personalized medicine · 2022Review
- Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury.Frontiers in immunology · 2022Review
- Effects and Mechanism of Constitutive TL1A Expression on Intestinal Mucosal Barrier in DSS-Induced Colitis.Digestive diseases and sciences · 2019Article
- Rifaximin Decreases the Incidence and Severity of Acute Kidney Injury and Hepatorenal Syndrome in Cirrhosis.Digestive diseases and sciences · 2016Article
- Exploring the Microbiome in Heart Failure.Current heart failure reports · 2016Review
- Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis.Journal of cardiac failure · 2015Review
- Intestinal barrier dysfunction in cirrhosis: Current concepts in pathophysiology and clinical implications.World journal of hepatology · 2015Article
- Procalcitonin, and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites.World journal of gastroenterology · 2014Article
- Splanchnic-aortic inflammatory axis in experimental portal hypertension.World journal of gastroenterology · 2013Review
- Gut-brain chemokine changes in portal hypertensive rats.Digestive diseases and sciences · 2011Article
- The interstitial lymphatic peritoneal mesothelium axis in portal hypertensive ascites: when in danger, go back to the sea.International journal of inflammation · 2010Article
- The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension.Journal of translational medicine · 2007Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBacterial translocation is a frequent complication in portal hypertension related to cirrhosis in the human clinical area. The aim of this study was to verify the existence of intestinal bacterial translocation to mesenteric lymph nodes in male Wistar rats with triple partial portal vein ligation during short- (48 h) and long-term (1 month) postoperative evolution.
resultsAt 48 h, ileal total aerobes bacteria (p < 0.001) and Lactobacillus decrease in sham-operated (SO) and portal hypertensive (PH) rats. At 1 month, ileal Enterococci and Streptococcus sp. show a statistically significant decrease in SO- and PH-rats. Lactobacillus decreases in the colon in SO- (p < 0.01) and in PH-rats (p < 0.001). At 1 month, colonic Enterococci decreases compared to control (p < 0.001) and SO-rats (p < 0.01). These intestinal microfloral changes are associated with bacterial translocation to mesenteric lymph nodes at 48 h (50%; p = 0.004) and 1 month (100%; p < 0.001) of postoperative evolution in PH-rats.
conclusionsThe enlargement of the stenosed portal tract related to triple partial portal vein ligation in the rat, since it increases the resistance to the portal blood flow, may be a key factor involved in one of the pathological consequences of portal hypertension, as is bacterial translocation to mesenteric lymph nodes.
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