ArticleInternational journal of legal medicine2010
Forensic application of intrarenal aquaporin-2 expression for differential diagnosis between freshwater and saltwater drowning.
Article in International journal of legal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Application of Aquaporins as Markers in Forensic Pathology: A Systematic Review of the Literature.International journal of molecular sciences · 2024Pooled it
- Kidney-Based Molecular Diagnostics of Freshwater Drowning: Comparative Evaluation of SP-A2 and AQP5 in an Animal Model.Diagnostics (Basel, Switzerland) · 2026Article
- Immunohistochemical cerebral cortex expression of aquaporin 4, aquaporin 5, aquaporin 9 Vasopressin and GFAP in saltwater drowning and freshwater drowning.International journal of legal medicine · 2026Article
- Post Mortem Molecular Biomarkers of Asphyxia: A Literature Review.International journal of molecular sciences · 2024Review
- Forensic Diagnosis of Freshwater or Saltwater Drowning Using the Marker Aquaporin 5: An Immunohistochemical Study.Medicina (Kaunas, Lithuania) · 2022Article
- Commentary on "Macromorphological findings in cases of death in water: a critical view on drowning signs".International journal of legal medicine · 2021Article
- Intrathrombotic appearances of AQP-1 and AQP-3 in relation to thrombus age in murine deep vein thrombosis model.International journal of legal medicine · 2021Article
- Mini Review: Forensic Value of Aquaporines.Frontiers in medicine · 2021Review
- Postmortem chest computed tomography for the diagnosis of drowning: a feasibility study.Forensic sciences research · 2021Article
- MicroRNAs: An Update of Applications in Forensic Science.Diagnostics (Basel, Switzerland) · 2020Review
- Immunohistochemical renal expression of aquaporin 2, arginine-vasopressin, vasopressin receptor 2, and renin in saltwater drowning and freshwater drowning.International journal of legal medicine · 2020Article
- Forensic application of epidermal AQP3 expression to determination of wound vitality in human compressed neck skin.International journal of legal medicine · 2018Article
- Distinction between saltwater drowning and freshwater drowning by assessment of sinus fluid on post-mortem computed tomography.European radiology · 2016Article
- Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination.International journal of legal medicine · 2015Article
- Immunohistochemical analysis on cyclooxygenase-2 for wound age determination.International journal of legal medicine · 2012Article
- Immunohistochemical detection of uPA, tPA, and PAI-1 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation.International journal of legal medicine · 2012Article
- Immunohistochemical examination of intracerebral aquaporin-4 expression and its application for differential diagnosis between freshwater and saltwater drowning.International journal of legal medicine · 2011Article
- Immunohistochemical detection of MMP-2 and MMP-9 in a stasis-induced deep vein thrombosis model and its application to thrombus age estimation.International journal of legal medicine · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquaporins (AQPs) are a family of homologous water channel proteins. In this study, the expressions of AQP1, 2, and 4 were immunohistochemically examined in kidney samples to evaluate their forensic applicability to differentiate between freshwater drowning (FWD) and saltwater drowning (SWD). Kidney samples were obtained from 51 drowning cases (23 FWD and 28 SWD) and 19 non-drowning cases. AQP1 was expressed in the proximal tubules and glomeruli, and AQP4 was localized in the collecting ducts. However, there were no significant differences in AQP1 and AQP4 expressions among FWD, SWD, and control groups. Immunohistochemically, AQP2 was predominantly expressed in the apical plasma membrane of the collecting duct principal cells in all kidney samples of FWD and SWD. Morphometrically, AQP2 expression at the apical plasma membrane of collecting ducts was significantly enhanced in SWD group, compared with FWD and control groups. On the other hand, AQP-2 expression was significantly lower in FWD group than in control group. Moreover, in drowning cases, there was no correlation between post-submersion intervals and AQP expression. From a forensic aspect, immunohistochemical detection of AQP2 in the kidney can be considered a valuable marker to differentiate between FWD and SWD.
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