ArticleWorld journal of urology2010
Arsenic exposure predicts bladder cancer survival in a US population.
Article in World journal of urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Toenails as a biomarker of exposure to arsenic: A review.Environmental research · 2021Pooled it
- Arsenic in drinking water and urinary tract cancers: a systematic review of 30 years of epidemiological evidence.Environmental health : a global access science source · 2014Pooled it
- Influence of the Levels of Arsenic, Cadmium, Mercury and Lead on Overall Survival in Lung Cancer.Biomolecules · 2021Article
- Occupational disparities in survival in Korean women with cancer: a nationwide registry linkage study.BMJ open · 2020Article
- Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC.DNA repair · 2017Article
- Risk of death from cardiovascular disease associated with low-level arsenic exposure among long-term smokers in a US population-based study.Toxicology and applied pharmacology · 2015Article
- Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio.Toxicology and applied pharmacology · 2012Article
- Genetic variation in glutathione S-transferase omega-1, arsenic methyltransferase and methylene-tetrahydrofolate reductase, arsenic exposure and bladder cancer: a case-control study.Environmental health : a global access science source · 2012Article
- Associations of toenail arsenic, cadmium, mercury, manganese, and lead with blood pressure in the normative aging study.Environmental health perspectives · 2012Article
- DNA methylation profiles delineate etiologic heterogeneity and clinically important subgroups of bladder cancer.Carcinogenesis · 2010Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
purposeChronic arsenic exposure at levels found in US drinking water has been associated with bladder cancer. While arsenic is a known carcinogen, recent studies suggest that it is useful as a therapeutic agent for leukemia. This study examined the relationship between arsenic exposure and bladder cancer mortality.
methodsWe studied 832 cases of bladder cancer diagnosed in New Hampshire from a population-based case-control study. Individual exposure to arsenic was determined in home drinking water using ICP-MS and in toenail samples by instrumental neutron activation analysis.
resultsAmong the high arsenic exposure group, found using toenail arsenic level or arsenic consumption, cases experienced a de-escalated survival hazard ratio (HR) [high (> or =75 percent) versus low (<25th percentile) toenail arsenic overall survival HR 0.5 (95% CI 0.4-0.8)], controlled for tumor stage, grade, gender, age and treatment regimen. This association was found largely among invasive tumors, in smokers and was not modified by TP53 status. Bladder cancer cause-specific survival showed a similar trend, but did not reach statistical significance [HR 0.5 (95% CI 0.3-1.1)].
conclusionsArsenic exposure may be related to the survival of patients with bladder cancer.
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