ArticleChemosensory perception2008
Merkel Cells in Somatosensation.
Article in Chemosensory perception, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Nipple shield use does not impact sucking dynamics in breastfeeding infants of mothers with nipple pain.European journal of pediatrics · 2021Trial
- Cellular and molecular changes in the skin driving increased nociception and pain during burn injury and repair.Frontiers in pain research (Lausanne, Switzerland) · 2026Review
- Merkel Cell Polyomavirus T Antigen-Mediated Reprogramming in Adult Merkel Cell Progenitors.The Journal of investigative dermatology · 2023Article
- Intestinal enteroendocrine cells rely on ryanodine and IPThe Journal of physiology · 2023Article
- Review
- Constraints on the deformation of the vibrissa within the follicle.PLoS computational biology · 2021Article
- Applications of Mesenchymal Stem Cells in Skin Regeneration and Rejuvenation.International journal of molecular sciences · 2021Review
- The importance of the neuro-immuno-cutaneous system on human skin equivalent design.Cell proliferation · 2019Review
- Dissection of Merkel cell formation in hairy and glabrous skin reveals a common requirement for FGFR2-mediated signalling.Experimental dermatology · 2019Article
- Static and active tactile perception and touch anisotropy: aging and gender effect.Scientific reports · 2018Article
- FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells.Nature communications · 2018Article
- Mechanotransduction in epidermal Merkel cells.Pflugers Archiv : European journal of physiology · 2015Review
- A quantitative sensory analysis of peripheral neuropathy in colorectal cancer and its exacerbation by oxaliplatin chemotherapy.Cancer research · 2014Article
- Diversification and specialization of touch receptors in skin.Cold Spring Harbor perspectives in medicine · 2014Review
- Epigenetic regulation of epidermal differentiation.Cold Spring Harbor perspectives in medicine · 2014Review
- Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells.The EMBO journal · 2013Article
- The role of Atonal transcription factors in the development of mechanosensitive cells.Seminars in cell & developmental biology · 2013Review
- Dendritic filopodia, Ripped Pocket, NOMPC, and NMDARs contribute to the sense of touch in Drosophila larvae.Current biology : CB · 2012Article
- The molecular basis of mechanosensory transduction.Advances in experimental medicine and biology · 2012Review
- Molecular mechanisms of mechanotransduction in mammalian sensory neurons.Nature reviews. Neuroscience · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Merkel cells are rare epidermal cells whose function in the skin is still debated. These cells localize to highly touch-sensitive areas of vertebrate epithelia, including palatine ridges, touch domes and finger tips. In most cases, Merkel cells complex with somatosensory afferents to form slowly adapting touch receptors; it is unclear, however, whether mechanosensory transduction occurs in the Merkel cell, the somatosensory afferent or both. Classic anatomical results suggests that Merkel cells are sensory cells that transduce mechanical stimuli and then communicate with sensory afferents via neurotransmission. This model is supported by recent molecular, immunohistochemical and physiological studies of Merkel cells in vitro and in intact tissues. For example, Merkel cells express essential components of presynaptic machinery, including molecules required for release of the excitatory neurotransmitter glutamate. Moreover, Merkel cells in vitro and in vivo are activated by mechanical stimuli, including hypotonic-induced cell swelling. Although these findings support the hypothesis that Merkel cells are sensory receptor cells, a definitive demonstration that Merkel cells are necessary and sufficient to transduce touch awaits future studies.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.