ReviewNature reviews. Genetics2009
The genetics of inbreeding depression.
Review in Nature reviews. Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 795 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
795 citing papers in PubMed, 1 synthesis or guideline pooled it, 2,215 citations in OpenAlex.
- Genomic investigations of successful invasions: the picture emerging from recent studies.Biological reviews of the Cambridge Philosophical Society · 2025Pooled it
- Mitogenomic characterisation of non-native freshwater snails in Australia: Implications for biosecurity and trematode vector surveillance.One health (Amsterdam, Netherlands) · 2026Article
- Balancing gain and diversity: Optimal contribution selection for sustainable genetic improvement in sugarcane.The plant genome · 2026Review
- Uncertainty-aware breeding decisions: MCMC-based optimum contribution selection increases breeding decision robustness.Genetics · 2026Article
- Bottlenecked but Booming: Strong Inbreeding in a Highly Invasive Freshwater Mussel.Molecular ecology · 2026Article
- Limited Lifetime Costs of Inbreeding in a Large Wild Population of Superb Fairy-Wrens.Molecular ecology · 2026Article
- Breakdown of dimorphic enantiostyly is linked to reduced herkogamy and increased self-pollination.Annals of botany · 2026Article
- Quantifying genetic load through joint modelling of inbreeding depression and inbreeding load for litter size in rabbits.Genetics, selection, evolution : GSE · 2026Article
- Pedigree structure, inbreeding, and survival analysis in an Irish Wolfhound cohort.Companion animal health and genetics · 2026Article
- Contrasting reproductive strategies and their functional consequences in two populations of Opuntia robusta (Cactaceae).BMC plant biology · 2026Article
- Sexual selection purges mutation load, but not overall genetic diversity, decreasing vulnerability to extinction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A highly contiguous genome assembly of Cyclamen persicum to accelerate functional genomics and breeding.DNA research : an international journal for rapid publication of reports on genes and genomes · 2026Article
- Allele frequencies at recessive disease genes are mainly determined by pleiotropic effects in heterozygotes.Genetics · 2026Article
- Modified meiosis in the tardigrade Hypsibius exemplaris maintains heterozygosity across the genome.Genetics · 2026Article
- Genetic Parameters and Sex-Specific Architecture of Observed and Latent Fertility Phenotypes in a Closed Breeding Nucleus of an Arctic Salmonid.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Varroa mites escape the evolutionary trap of haplodiploidy.Nature communications · 2026Article
- Selective Breeding for Voluntary Wheel-Running Behavior in Mice is not Associated with Reduced Lifetime Reproductive Success or Lifespan Under Long-Term Paired Breeding Conditions.Behavior genetics · 2026Article
- Analysis of Inbreeding, Population Structure, and Genetic Diversity in the Kumamoto Sub-Breed of Japanese Brown Cattle.Animals : an open access journal from MDPI · 2026Article
- A roadmap to key traits of invasive Drosophilidae.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Massive Genetic Diversity Loss Within Asian Elephant Subspecies: New Insights for Determining Conservation Priorities.Genome biology and evolution · 2026Article
735 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Commented on by
- Commented on by
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Inbreeding depression - the reduced survival and fertility of offspring of related individuals - occurs in wild animal and plant populations as well as in humans, indicating that genetic variation in fitness traits exists in natural populations. Inbreeding depression is important in the evolution of outcrossing mating systems and, because intercrossing inbred strains improves yield (heterosis), which is important in crop breeding, the genetic basis of these effects has been debated since the early twentieth century. Classical genetic studies and modern molecular evolutionary approaches now suggest that inbreeding depression and heterosis are predominantly caused by the presence of recessive deleterious mutations in populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.