ArticleArteriosclerosis, thrombosis, and vascular biology2010
Molecular imaging of the initial inflammatory response in atherosclerosis: implications for early detection of disease.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02246101 (Renal and Cardiovascular Impairment in WTC Responders), which is not on this map. Cited by 89 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Renal and Cardiovascular Impairment in WTC Responders: Implications for Diagnosis and Treatment
Who cites it
89 citing papers in PubMed, 187 citations in OpenAlex.
- Inflammasome inhibition in myocardial infarction reduces early reperfusion injury and suppresses systemic plaque activation.Atherosclerosis · 2026Article
- In Vivo Cardiovascular Molecular Imaging: Contributions to Precision Medicine and Drug Development.Circulation · 2024Review
- Removal of endothelial surface-associated von villebrand factor suppresses accelerate datherosclerosis after myocardial infarction.Journal of translational medicine · 2024Article
- Advances in Clinical Imaging of Vascular Inflammation: A State-of-the-Art Review.JACC. Basic to translational science · 2024Review
- Influence of Atherosclerotic Risk Factors on the Effectiveness of Therapeutic Ultrasound Cavitation for Flow Augmentation.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2024Article
- Liraglutide Lowers Endothelial Vascular Cell Adhesion Molecule-1 in Murine Atherosclerosis Independent of Glucose Levels.JACC. Basic to translational science · 2023Article
- Contrast-Enhanced Ultrasound Molecular Imaging in Atherosclerosis Research.Methods in molecular biology (Clifton, N.J.) · 2022Article
- CD11b-Based Pre-Targeted SPECT/CT Imaging Allows for the Detection of Inflammation in Aortic Aneurysm.Journal of inflammation research · 2022Article
- A kit-based aluminium-[Chemical communications (Cambridge, England) · 2021Article
- Nanobodies for Medical Imaging: About Ready for Prime Time?Biomolecules · 2021Review
- Echocardiographic Molecular Imaging of the Effect of Anticytokine Therapy for Atherosclerosis.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2021Article
- Molecular Ultrasound Imaging.Nanomaterials (Basel, Switzerland) · 2020Review
- Ultrasound molecular imaging: insights into cardiovascular pathology.Journal of echocardiography · 2020Review
- Monoclonal antibody-based molecular imaging strategies and theranostic opportunities.Theranostics · 2020Review
- Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe.International journal of nanomedicine · 2020Article
- Region-resolved proteomics profiling of monkey heart.Journal of cellular physiology · 2019Article
- Ultrasound Molecular Imaging: Principles and Applications in Cardiovascular Medicine.Current cardiology reports · 2019Review
- Molecular Imaging of a New Multimodal Microbubble for Adhesion Molecule Targeting.Cellular and molecular bioengineering · 2019Article
- Assessment of Novel Antioxidant Therapy in Atherosclerosis by Contrast Ultrasound Molecular Imaging.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2018Article
- Myocardial Infarction Produces Sustained Proinflammatory Endothelial Activation in Remote Arteries.Journal of the American College of Cardiology · 2018Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
unlabelledBackground- We hypothesized that molecular imaging of endothelial cell adhesion molecule expression could noninvasively evaluate prelesion atherogenic phenotype. METHODS AND
resultsMice deficient for the LDL-receptor and the Apobec-1 editing peptide (DKO mice) were studied as an age-dependent model of atherosclerosis. At 10, 20, and 40 weeks of age, ultrasound molecular imaging of the proximal thoracic aorta was performed with contrast agents targeted to P-selectin and VCAM-1. Atherosclerotic lesion severity and content were assessed by ultrahigh frequency ultrasound, histology, and immunohistochemistry. In wild-type mice at all ages, there was neither aortic thickening nor targeted tracer signal enhancement. In DKO mice, lesions progressed from sparse mild intimal thickening at 10 weeks to widespread severe lesions with luminal encroachment at 40 weeks. Molecular imaging for P-selectin and VCAM-1 demonstrated selective signal enhancement (P<0.01 versus nontargeted agent) at all ages for DKO mice. P-selectin and VCAM-1 signal in DKO mice were greater by 3-fold at 10 weeks, 4- to 6-fold at 20 weeks, and 9- to 10-fold at 40 weeks compared to wild-type mice. En face microscopy demonstrated preferential attachment of targeted microbubbles to regions of lesion formation.
conclusionsNoninvasive ultrasound molecular imaging of endothelial activation can detect lesion-prone vascular phenotype before the appearance of obstructive atherosclerotic lesions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.