ArticleInvestigative ophthalmology & visual science2010
Restricted localization of ponli, a novel zebrafish MAGUK-family protein, to the inner segment interface areas between green, red, and blue cones.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 16 citations in OpenAlex.
- Dscamb regulates cone mosaic formation in zebrafish via filopodium-mediated homotypic recognition.Nature communications · 2025Article
- The Lego hypothesis of tissue morphogenesis: stereotypic organization of parallel orientational cell adhesions for epithelial self-assembly.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Zebrafish Crb1, Localizing Uniquely to the Cell Membranes around Cone Photoreceptor Axonemes, Alleviates Light Damage to Photoreceptors and Modulates Cones' Light Responsiveness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Identification and Characterization of Cis-Regulatory Elements for Photoreceptor-Type-Specific Transcription in ZebraFish.Methods in molecular biology (Clifton, N.J.) · 2020Article
- A novel transgenic zebrafish line for red opsin expression in outer segments of photoreceptor cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2018Article
- Article
- Patterning the cone mosaic array in zebrafish retina requires specification of ultraviolet-sensitive cones.PloS one · 2014Article
- Spatial-temporal expressions of Crumbs and Nagie oko and their interdependence in zebrafish central nervous system during early development.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2013Article
- The cone-dominant retina and the inner ear of zebrafish express the ortholog of CLRN1, the causative gene of human Usher syndrome type 3A.Gene expression patterns : GEP · 2013Article
- Structural disorganization of pronephric glomerulus in zebrafish mpp5a/nagie oko mutant.Developmental dynamics : an official publication of the American Association of Anatomists · 2012Article
- Crb apical polarity proteins maintain zebrafish retinal cone mosaics via intercellular binding of their extracellular domains.Developmental cell · 2012Article
- Coupling mechanical deformations and planar cell polarity to create regular patterns in the zebrafish retina.PLoS computational biology · 2012Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeThe inner segments (IS) of the photoreceptors in vertebrates are enriched with polarity scaffold proteins, which maintain the integrity of many tissues by mediating cell-cell adhesion either directly or indirectly. The formation of photoreceptor mosaics may require differential adhesion among different types of photoreceptors. It is unknown whether any polarity proteins are selectively expressed in certain photoreceptors to mediate differential intercellular adhesion, which may be important for photoreceptor patterning. This study was undertaken to identify such polarity proteins.
methodsTo identify novel MAGUK-family (membrane-associated guanylate kinase) proteins that are similar to Nagie oko (Nok), the authors performed BLAST searches of the zebrafish genome with the Nok amino acid sequence as the query. The coding sequence of one of the identified genes was obtained and verified through RT-PCR and RACE (rapid amplification of cDNA ends). Its protein expression patterns were examined by immunomicroscopy and Western blot analysis. Morpholino knockdown technology was used for loss-of-function analyses.
resultsThe authors cloned a novel nok homolog and designated it photoreceptor-layer-nok-like (ponli). Unlike Nok, which is expressed broadly, Ponli is only expressed at the interface areas between the IS of the green, red, and blue cones in differentiated zebrafish retina.
conclusionsPonli is the first identified polarity protein that is not expressed in all types of photoreceptors. Ponli's selective distribution stimulates future investigations on its functions for photoreceptor mosaic formation.
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