ArticleJournal of the American Society of Nephrology : JASN2009
Three-dimensional imaging reveals ureteric and mesenchymal defects in Fgfr2-mutant kidneys.
Article in Journal of the American Society of Nephrology : JASN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 46 citations in OpenAlex.
- Aberrations inInternational journal of molecular sciences · 2022Article
- Immunohistochemical Expression Pattern of FGFR1, FGFR2, RIP5, and HIP2 in Developing and Postnatal Kidneys ofInternational journal of molecular sciences · 2022Article
- Organ-Specific Branching Morphogenesis.Frontiers in cell and developmental biology · 2021Review
- FGF/FGFR signaling in health and disease.Signal transduction and targeted therapy · 2020Review
- Von Hippel-Lindau Acts as a Metabolic Switch Controlling Nephron Progenitor Differentiation.Journal of the American Society of Nephrology : JASN · 2019Article
- Mathematical Approaches of Branching Morphogenesis.Frontiers in genetics · 2018Review
- Endothelial marker-expressing stromal cells are critical for kidney formation.American journal of physiology. Renal physiology · 2017Article
- Fgfr2 is integral for bladder mesenchyme patterning and function.American journal of physiology. Renal physiology · 2017Article
- The contribution of branching morphogenesis to kidney development and disease.Nature reviews. Nephrology · 2016Review
- Six2creFrs2α knockout mice are a novel model of renal cystogenesis.Scientific reports · 2016Article
- Ablation of the epithelial-specific splicing factor Esrp1 results in ureteric branching defects and reduced nephron number.Developmental dynamics : an official publication of the American Association of Anatomists · 2016Article
- Fibroblast growth factor receptor signaling in kidney and lower urinary tract development.Pediatric nephrology (Berlin, Germany) · 2016Review
- Prorenin receptor is critical for nephron progenitors.Developmental biology · 2016Article
- Fgfr2 is integral for bladder mesenchyme patterning and function.American journal of physiology. Renal physiology · 2015Article
- Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors.Developmental biology · 2015Article
- Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia.The Journal of pediatrics · 2015Article
- An integrated pipeline for the multidimensional analysis of branching morphogenesis.Nature protocols · 2014Article
- Vesicoureteric reflux and reflux nephropathy: from mouse models to childhood disease.Pediatric nephrology (Berlin, Germany) · 2014Review
- Histologic evidence of intrapulmonary anastomoses by three-dimensional reconstruction in severe bronchopulmonary dysplasia.Annals of the American Thoracic Society · 2013Article
- The control of branching morphogenesis.Open biology · 2013Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Current techniques to morphologically characterize the processes of nephrogenesis and ureteric branching during kidney development have many limitations. Here, we used in vivo three-dimensional analysis to study renal development in mice lacking fibroblast growth factor receptor 2 in the ureteric bud (Fgfr2(UB-/-)) and in littermate controls. We found that Fgfr2(UB-/-) mice have more severe defects in ureteric branching morphogenesis than previously reported, including significantly fewer branches and tips than control mice. Furthermore, these mice had decreased ureteric volume and surface area and longer ureteric segments than control mice. We also observed previously unrecognized abnormalities in nephrogenesis, including a gradual increase in volume and surface area during maturation from renal vesicles to mature nephrons, in the mutant mice. Finally, we quantified many events of normal renal development that are either difficult or impossible to measure without this three-dimensional technique. In summary, the three-dimensional approach is a powerful and quantitative means to characterize branching morphogenesis and nephrogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.