ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2009
Oral PEG 15-20 protects the intestine against radiation: role of lipid rafts.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
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- Consequences of poly(ethylene oxide) and poloxamer P188 on transcription in healthy and stressed myoblasts.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Rationale behind phosphate therapy to modulate the gut microbiome and protect against surgery-related infection.Microbiota and host · 2023Article
- Concentration Threshold for Membrane Protection by PEO-PPO Block Copolymers with Variable Molecular Architectures.ACS applied polymer materials · 2022Article
- Article
- Probiotic Lactobacillus reuteri Prevents Postantibiotic Bone Loss by Reducing Intestinal Dysbiosis and Preventing Barrier Disruption.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Sustained Release of Phosphates From Hydrogel Nanoparticles Suppresses Bacterial Collagenase and Biofilm FormationFrontiers in bioengineering and biotechnology · 2019Article
- Glycocalyx Preservation and NO Production in Fatty Livers-The Protective Role of High Molecular Polyethylene Glycol in Cold Ischemia Injury.International journal of molecular sciences · 2018Article
- High Molecular Weight Polymer Promotes Bone Health and Prevents Bone Loss UnderFrontiers in physiology · 2018Article
- High-molecular-weight polyethylene glycol inhibits myocardial ischemia-reperfusion injury in vivo.The Journal of thoracic and cardiovascular surgery · 2015Article
- Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens.Antimicrobial agents and chemotherapy · 2014Article
- High molecular weight polyethylene glycol (PEG 15-20) maintains mucosal microbial barrier function during intestinal graft preservation.The Journal of surgical research · 2013Article
- Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- Recent advances in small bowel diseases: Part II.World journal of gastroenterology · 2012Review
- Pseudomonas aeruginosa virulence expression is directly activated by morphine and is capable of causing lethal gut-derived sepsis in mice during chronic morphine administration.Annals of surgery · 2012Article
- Intestinal tissues induce an SNP mutation in Pseudomonas aeruginosa that enhances its virulence: possible role in anastomotic leak.PloS one · 2012Article
- Protective effects of nonionic triblock copolymers on bile acid-mediated epithelial barrier disruption.Shock (Augusta, Ga.) · 2011Article
- High-molecular-weight polyethylene glycol protects cardiac myocytes from hypoxia- and reoxygenation-induced cell death and preserves ventricular function.American journal of physiology. Heart and circulatory physiology · 2011Article
- Higher molecular weight polyethylene glycol increases cell proliferation while improving barrier function in an in vitro colon cancer model.Journal of biomedicine & biotechnology · 2011Article
- Host stress and virulence expression in intestinal pathogens: development of therapeutic strategies using mice and C. elegans.Current pharmaceutical design · 2011Review
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 1 country.
Funding
Abstract
Intestinal injury following abdominal radiation therapy or accidental exposure remains a significant clinical problem that can result in varying degrees of mucosal destruction such as ulceration, vascular sclerosis, intestinal wall fibrosis, loss of barrier function, and even lethal gut-derived sepsis. We determined the ability of a high-molecular-weight polyethylene glycol-based copolymer, PEG 15-20, to protect the intestine against the early and late effects of radiation in mice and rats and to determine its mechanism of action by examining cultured rat intestinal epithelia. Rats were exposed to fractionated radiation in an established model of intestinal injury, whereby an intestinal segment is surgically placed into the scrotum and radiated daily. Radiation injury score was decreased in a dose-dependent manner in rats gavaged with 0.5 or 2.0 g/kg per day of PEG 15-20 (n = 9-13/group, P < 0.005). Complementary studies were performed in a novel mouse model of abdominal radiation followed by intestinal inoculation with Pseudomonas aeruginosa (P. aeruginosa), a common pathogen that causes lethal gut-derived sepsis following radiation. Mice mortality was decreased by 40% in mice drinking 1% PEG 15-20 (n = 10/group, P < 0.001). Parallel studies were performed in cultured rat intestinal epithelial cells treated with PEG 15-20 before radiation. Results demonstrated that PEG 15-20 prevented radiation-induced intestinal injury in rats, prevented apoptosis and lethal sepsis attributable to P. aeruginosa in mice, and protected cultured intestinal epithelial cells from apoptosis and microbial adherence and possible invasion. PEG 15-20 appeared to exert its protective effect via its binding to lipid rafts by preventing their coalescence, a hallmark feature in intestinal epithelial cells exposed to radiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.