ArticleAJNR. American journal of neuroradiology2010
Contrast-enhancement of the anterior eye segment in patients with retinoblastoma: correlation between clinical, MR imaging, and histopathologic findings.
Article in AJNR. American journal of neuroradiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Practical guidelines on imaging of retinoblastoma: a 2025 update on behalf of the European Retinoblastoma Imaging Collaboration and the European Retinoblastoma Group.European radiology · 2026Guideline
- Diagnostic performance of MRI of post-laminar optic nerve invasion detection in retinoblastoma: A systematic review and meta-analysis.Neuroradiology · 2021Pooled it
- Guidelines for imaging retinoblastoma: imaging principles and MRI standardization.Pediatric radiology · 2012Guideline
- The impact of vitreous humor: a new perspective on radiation-induced cataractogenesis.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Comparison of HASTE versus EPI-Based DWI for Retinoblastoma and Correlation with Prognostic Histopathologic Parameters.AJNR. American journal of neuroradiology · 2024Article
- MRI Features for IdentifyingRadiology · 2023Article
- Imaging Techniques in the Diagnosis and Management of Ocular Tumors: Prospects and Challenges.The AAPS journal · 2018Review
- Correlation between conventional MR imaging combined with diffusion-weighted imaging and histopathologic findings in eyes primarily enucleated for advanced retinoblastoma: a retrospective study.European radiology · 2018Article
- MRI helps depict clinically undetectable risk factors in advanced stage retinoblastomas.The neuroradiology journal · 2015Article
- Comparison of the diagnostic value of MR imaging and ophthalmoscopy for the staging of retinoblastoma.European radiology · 2013Article
- Retinoblastoma: value of dynamic contrast-enhanced MR imaging and correlation with tumor angiogenesis.AJNR. American journal of neuroradiology · 2012Article
- Correlation of apparent diffusion coefficient at 3T with prognostic parameters of retinoblastoma.AJNR. American journal of neuroradiology · 2012Article
- MRI of retinoblastoma.The British journal of radiology · 2011Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeAES contrast-enhancement is recognized in a substantial number of retinoblastoma-affected eyes. We retrospectively investigated the histopathologic basis of AES contrast-enhancement on MR images in retinoblastoma. MATERIALS AND
methodsPretreatment contrast-enhanced MR images were obtained from 42 children with retinoblastoma. Forty-two enucleated eyes were included in this study, AES enhancement was evaluated by using a 3-point score, and these data were correlated with clinical, MR imaging, and histopathologic findings. Additionally, 14 specimens were immunohistochemically analyzed for CD31, VEGF, and Flt-1 expression. Statistical correlations with AES enhancement were assessed by using a linear-by-linear association test and univariate and multivariate ordinal regressions.
resultsThe degree of abnormal AES enhancement was moderate in 15 (36%) eyes and strong in 14 (33%) eyes, whereas 13 (31%) eyes showed normal AES enhancement. In multivariate analysis, the degree of AES enhancement showed statistically significant correlations with iris surface-vessel count (P = .05) and optic nerve invasion (P = .04) in the enucleated eye and with tumor volume (P = .02) as detected on MR imaging. No significant associations between AES enhancement and VEGF expression in the iris were observed. Flt-1 (P = .04) staining in iris stroma and IA as detected with CD31 staining (P = .009) both yielded a statistically significant positive correlation with abnormal AES enhancement.
conclusionsThe degree of abnormal AES enhancement on MR imaging in retinoblastoma reflects angiogenesis in the iris. AES enhancement is also a hallmark of advanced retinoblastoma because its degree correlates with tumor volume and optic nerve invasion.
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