ArticleGenes & development2009
HARPing on about the DNA damage response during replication.
Article in Genes & development, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 39 citations in OpenAlex.
- Chromatin regulator SMARCAL1 modulates cellular lipid metabolism.Communications biology · 2023Article
- The helicase domain of Polθ counteracts RPA to promote alt-NHEJ.Nature structural & molecular biology · 2017Article
- Article
- Annealing helicase HARP closes RPA-stabilized DNA bubbles non-processively.Nucleic acids research · 2017Article
- Ewing Tumor-associated Antigen 1 Interacts with Replication Protein A to Promote Restart of Stalled Replication Forks.The Journal of biological chemistry · 2016Article
- Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression.Epigenetics & chromatin · 2013Article
- Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Regulation of PCNA-protein interactions for genome stability.Nature reviews. Molecular cell biology · 2013Review
- Rescuing stalled or damaged replication forks.Cold Spring Harbor perspectives in biology · 2013Review
- Synthetic lethality and cancer: cohesin and PARP at the replication fork.Trends in genetics : TIG · 2013Review
- Chromatin and the genome integrity network.Nature reviews. Genetics · 2013Review
- BLM SUMOylation regulates ssDNA accumulation at stalled replication forks.Frontiers in genetics · 2013Article
- Human DNA helicase B (HDHB) binds to replication protein A and facilitates cellular recovery from replication stress.The Journal of biological chemistry · 2012Article
- SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication.Genes & development · 2012Article
- Unwinding and rewinding: double faces of helicase?Journal of nucleic acids · 2012Article
- Rituximab resistant evans syndrome and autoimmunity in Schimke immuno-osseous dysplasia.Pediatric rheumatology online journal · 2011Article
- Non-hodgkin lymphoma in a child with schimke immuno-osseous dysplasia.Iranian journal of medical sciences · 2011Article
- Coordinated protein and DNA remodeling by human HLTF on stalled replication fork.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- E3 ligase RFWD3 participates in replication checkpoint control.The Journal of biological chemistry · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In this issue of Genes & Development, four papers report that the annealing helicase HepA-related protein (HARP, also known as SMARCAL1 [SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a-like 1]) binds directly to the ssDNA-binding protein Replication protein A (RPA) and is recruited to sites of replicative stress. Knockdown of HARP results in hypersensitivity to multiple DNA-damaging agents and defects in fork stability or restart. These exciting insights reveal a key new player in the S-phase DNA damage response.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.