ArticleThe Journal of biological chemistry2009
Migfilin interacts with Src and contributes to cell-matrix adhesion-mediated survival signaling.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Migfilin promotes autophagic flux through direct interaction with SNAP29 and Vamp8.The Journal of cell biology · 2024Article
- Migfilin: Cell Adhesion Effect and Comorbidities.OncoTargets and therapy · 2022Review
- Cancer Stem Cells: Emergent Nature of Tumor Emergency.Frontiers in genetics · 2018Article
- Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis.Frontiers in oncology · 2018Review
- Inhibition of PTP1B disrupts cell-cell adhesion and induces anoikis in breast epithelial cells.Cell death & disease · 2017Article
- Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases.Scientific reports · 2016Article
- Accumulation of cholesterol and increased demand for zinc in serum-deprived RPE cells.Molecular vision · 2016Article
- Expression of migfilin is increased in esophageal cancer and represses the Akt-β-catenin activation.American journal of cancer research · 2014Article
- Role of the IL-6-JAK1-STAT3-Oct-4 pathway in the conversion of non-stem cancer cells into cancer stem-like cells.Cellular signalling · 2013Article
- Migfilin, α-parvin and β-parvin are differentially expressed in ovarian serous carcinoma effusions, primary tumors and solid metastases.Gynecologic oncology · 2013Article
- Claudin-1 expression confers resistance to anoikis in colon cancer cells in a Src-dependent manner.Carcinogenesis · 2012Article
- Migfilin sensitizes cisplatin-induced apoptosis in human glioma cells in vitro.Acta pharmacologica Sinica · 2012Article
- Critical role of filamin-binding LIM protein 1 (FBLP-1)/migfilin in regulation of bone remodeling.The Journal of biological chemistry · 2012Article
- Acquisition of anoikis resistance through CD147 upregulation: A new mechanism underlying metastasis of hepatocellular carcinoma cells.Oncology letters · 2012Article
- In vitro imaging of angiogenesis using embryonic stem cell-derived endothelial cells.Stem cells and development · 2012Article
- Mining gene expression signature for the detection of pre-malignant melanocytes and early melanomas with risk for metastasis.PloS one · 2012Article
- Excessive hepatomegaly of mice with hepatocyte-targeted elimination of integrin linked kinase following treatment with 1,4-bis [2-(3,5-dichaloropyridyloxy)] benzene.Hepatology (Baltimore, Md.) · 2011Article
- Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Integrin-mediated cell-extracellular matrix (ECM) adhesion is essential for protection of epithelial cells against apoptosis, but the underlying mechanism is incompletely understood. Here we show that migfilin, an integrin-proximal adaptor protein, interacts with Src and contributes to cell-ECM-mediated survival signaling. Loss of cell-ECM adhesion markedly reduces the migfilin level in untransformed epithelial cells and concomitantly induces apoptosis. Overexpression of migfilin substantially desensitizes cell detachment-induced apoptosis. Conversely, depletion of migfilin promotes apoptosis despite the presence of cell-ECM adhesion. At the molecular level migfilin directly interacts with Src, and the migfilin binding surface overlaps with the inhibitory intramolecular interaction sites in Src. Consequently, the binding of migfilin activates Src, resulting in suppression of apoptosis. Our results reveal a novel mechanism by which cell-ECM adhesion regulates Src activation and survival signaling. This migfilin-mediated signaling pathway is dysfunctional in multiple types of carcinoma cells, which likely contributes to aberrant Src activation and anoikis resistance in the cancerous cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.