ArticleThe Journal of biological chemistry2009
Structural characterization of mouse neutrophil serine proteases and identification of their substrate specificities: relevance to mouse models of human inflammatory diseases.
Article in The Journal of biological chemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 51 citations in OpenAlex.
- Endothelial Dysfunction and Neutrophil Degranulation as Central Events in Sepsis Physiopathology.International journal of molecular sciences · 2021Review
- Proteolytic cleavage of HLA class II by human neutrophil elastase in pneumococcal pneumonia.Scientific reports · 2021Article
- Establishment of a Risk Score Model for Early Prediction of Severe H1N1 Influenza.Frontiers in cellular and infection microbiology · 2021Article
- Neutrophil Elastase Activity Imaging: Recent Approaches in the Design and Applications of Activity-Based Probes and Substrate-Based Probes.Contrast media & molecular imaging · 2019Review
- Neutrophil Elastase Subverts the Immune Response by Cleaving Toll-Like Receptors and Cytokines in Pneumococcal Pneumonia.Frontiers in immunology · 2018Article
- Pseudomonas aeruginosa proteolytically alters the interleukin 22-dependent lung mucosal defense.Virulence · 2017Article
- N-Formyl-Perosamine Surface Homopolysaccharides Hinder the Recognition of Brucella abortus by Mouse Neutrophils.Infection and immunity · 2016Article
- Mast cell proteases as pharmacological targets.European journal of pharmacology · 2016Review
- The Pig: A Relevant Model for Evaluating the Neutrophil Serine Protease Activities during Acute Pseudomonas aeruginosa Lung Infection.PloS one · 2016Article
- Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- The pig as a model for investigating the role of neutrophil serine proteases in human inflammatory lung diseases.The Biochemical journal · 2012Article
- Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase.Nature medicine · 2012Article
- Critical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes.BMC research notes · 2012Article
- Cathepsin G and neutrophil elastase play critical and nonredundant roles in lung-protective immunity against Streptococcus pneumoniae in mice.Infection and immunity · 2011Article
- Noninvasive in vivo quantification of neutrophil elastase activity in acute experimental mouse lung injury.International journal of molecular imaging · 2011Article
- Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.Pharmacological reviews · 2010Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is widely accepted that neutrophil serine proteases (NSPs) play a critical role in neutrophil-associated lung inflammatory and tissue-destructive diseases. To investigate NSP pathogenic role(s), various mouse experimental models have been developed that mimic acutely or chronically injured human lungs. We and others are using mouse exposure to cigarette smoke as a model for chronic obstructive pulmonary disease with or without exacerbation. However, the relative contribution of NSPs to lung disease processes as well as their underlying mechanisms remains still poorly understood. And the lack of purified mouse NSPs and their specific substrates have hampered advances in these studies. In this work, we compared mouse and human NSPs and generated three-dimensional models of murine NSPs based on three-dimensional structures of their human homologs. Analyses of these models provided compelling evidence that peptide substrate specificities of human and mouse NSPs are different despite their conserved cleft and close structural resemblance. These studies allowed us to synthesize for the first time novel sensitive fluorescence resonance energy transfer substrates for individual mouse NSPs. Our findings and the newly identified substrates should better our understanding about the role of NSPs in the pathogenesis of cigarette-associated chronic obstructive pulmonary disease as well as other neutrophils-associated inflammatory diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.