ArticleChemical senses2009
Double P2X2/P2X3 purinergic receptor knockout mice do not taste NaCl or the artificial sweetener SC45647.
Article in Chemical senses, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- A systematic review of the biological mediators of fat taste and smell.Physiological reviews · 2023Pooled it
- Functional role of peripheral P2X3 receptor expression in trigeminal ganglion neurons: a microarray-based evaluation of the antagonist effect of P2X3.Purinergic signalling · 2026Article
- A hypothesis connecting dysgeusia due to defects in ATP-P2X3 signaling and fatigue in myalgic encephalomyelitis/chronic fatigue syndrome: lessons learned from long-COVID.Frontiers in medicine · 2026Article
- Possible Roles for Purinergic Receptor P2RX4 in Breast and Prostate Cancers.International journal of molecular sciences · 2025Review
- The New Wave of Blocking Taste.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Safety, Tolerability, and Pharmacokinetics of Filapixant, a Highly Selective P2X3 Receptor Antagonist, in an Ascending-Single-Dose First-in-Human Study.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Bitter and Sweet Diets Alter Taste Response and Alcohol Consumption Behavior in Mice.Nutrients · 2025Article
- Article
- Give-and-take of gustation: the interplay between gustatory neurons and taste buds.Chemical senses · 2024Review
- The elusive cephalic phase insulin response: triggers, mechanisms, and functions.Physiological reviews · 2023Review
- Taste Receptors beyond Taste Buds.International journal of molecular sciences · 2022Review
- SARS-CoV-2 infection of human-induced pluripotent stem cells-derived lung lineage cells evokes inflammatory and chemosensory responses by targeting mitochondrial pathways.Journal of cellular physiology · 2022Article
- Follow Your Nose: A Key Clue to Understanding and Treating COVID-19.Frontiers in endocrinology · 2021Article
- An alternative pathway for sweet sensation: possible mechanisms and physiological relevance.Pflugers Archiv : European journal of physiology · 2020Review
- Cyclophosphamide-Induced Disruptions to Appetitive Qualities and Detection Thresholds of NaCl: Comparison of Single-Dose and Dose Fractionation Effects.Chemical senses · 2018Article
- BDNF is required for taste axon regeneration following unilateral chorda tympani nerve section.Experimental neurology · 2017Article
- Immunocytochemical organization and sour taste activation in the rostral nucleus of the solitary tract of mice.The Journal of comparative neurology · 2017Article
- Measurement of Behavioral Taste Responses in Mice: Two-Bottle Preference, Lickometer, and Conditioned Taste-Aversion Tests.Current protocols in mouse biology · 2016Article
- Normal Taste Acceptance and Preference of PANX1 Knockout Mice.Chemical senses · 2015Article
- Postsynaptic P2X3-containing receptors in gustatory nerve fibres mediate responses to all taste qualities in mice.The Journal of physiology · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The P2X ionotropic purinergic receptors, P2X2 and P2X3, are essential for transmission of taste information from taste buds to the gustatory nerves. Mice lacking both P2X2 and P2X3 purinergic receptors (P2X2/P2X3(Dbl-/-)) exhibit no taste-evoked activity in the chorda tympani and glossopharyngeal nerves when stimulated with taste stimuli from any of the 5 classical taste quality groups (salt, sweet, sour, bitter, and umami) nor do the mice show taste preferences for sweet or umami, or avoidance of bitter substances (Finger et al. 2005. ATP signaling is crucial for communication from taste buds to gustatory nerves. Science. 310[5753]:1495-1499). Here, we compare the ability of P2X2/P2X3(Dbl-/-) mice and P2X2/P2X3(Dbl+/+) wild-type (WT) mice to detect NaCl in brief-access tests and conditioned aversion paradigms. Brief-access testing with NaCl revealed that whereas WT mice decrease licking at 300 mM and above, the P2X2/P2X3(Dbl-/-) mice do not show any change in lick rates. In conditioned aversion tests, P2X2/P2X3(Dbl-/-) mice did not develop a learned aversion to NaCl or the artificial sweetener SC45647, both of which are easily avoided by conditioned WT mice. The inability of P2X2/P2X3(Dbl-/-) mice to show avoidance of these taste stimuli was not due to an inability to learn the task because both WT and P2X2/P2X3(Dbl-/-) mice learned to avoid a combination of SC45647 and amyl acetate (an odor cue). These data suggest that P2X2/P2X3(Dbl-/-) mice are unable to respond to NaCl or SC45647 as taste stimuli, mirroring the lack of gustatory nerve responses to these substances.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.