ReviewAgeing research reviews2010
Hypothermia as a cytoprotective strategy in ischemic tissue injury.
Review in Ageing research reviews, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Effect of hypothermic perfusion on phacoemulsification in cataract patients complicated with uveitis: a randomised trial.BMC ophthalmology · 2020Trial
- From diet to brain repair: natural bioactive compounds in post-ischemic stroke recovery.Frontiers in nutrition · 2026Review
- Optimizing brain protection after cardiac arrest: advanced strategies and best practices.Interface focus · 2024Review
- Article
- The forgotten art of cold therapeutic properties in cancer: A comprehensive historical guide.iScience · 2023Review
- Differential effects of hypothermia on neurovascular unit determine protective or toxic results: Toward optimized therapeutic hypothermia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Transient selective brain cooling confers neurovascular and functional protection from acute to chronic stages of ischemia/reperfusion brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2019Article
- Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease.Current medicinal chemistry · 2019Review
- Plasma Glycoproteomic Study of Therapeutic Hypothermia Reveals Novel Markers Predicting Neurologic Outcome Post-cardiac Arrest.Translational stroke research · 2018Article
- Myocardial histology and outcome after cardiopulmonary bypass of neonatal piglets.Journal of cardiothoracic surgery · 2015Article
- Therapeutic hypothermia for acute brain injuries.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Review
- Downregulation of metabolic activity increases cell survival under hypoxic conditions: potential applications for tissue engineering.Tissue engineering. Part A · 2014Article
- Article
- Article
- Myocardial protection against global ischemia with Krebs-Henseleit buffer-based cardioplegic solution.Journal of cardiothoracic surgery · 2013Article
- Time-dependent effects of hypothermia on microglial activation and migration.Journal of neuroinflammation · 2012Article
- A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Stroke research at a crossroad: asking the brain for directions.Nature neuroscience · 2011Article
- Cold pre-conditioning neuroprotection depends on TNF-α and is enhanced by blockade of interleukin-11.Journal of neurochemistry · 2011Article
- Experimental and clinical use of therapeutic hypothermia for ischemic stroke: opportunities and limitations.Stroke research and treatment · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hypothermia is a well established cytoprotectant, with remarkable and consistent effects demonstrated across multiple laboratories. At the clinical level, it has recently been shown to improve neurological outcome following cardiac arrest and neonatal hypoxia-ischemia. It is increasingly being embraced by the medical community, and could be considered an effective neuroprotectant. Conditions such as brain injury, hepatic encephalopathy and cardiopulmonary bypass seem to benefit from this intervention. It's role in direct myocardial protection is also being explored. A review of the literature has demonstrated that in order to appreciate the maximum benefits of hypothermia, cooling needs to begin soon after the insult, and maintained for relatively long period periods of time. In the case of ischemic stroke, cooling should ideally be applied in conjunction with the re-establishment of cerebral perfusion. Translating this to the clinical arena can be challenging, given the technical challenges of rapidly and stably cooling patients. This review will discuss the application of hypothermia especially as it pertains to its effects neurological outcome, cooling methods, and important parameters in optimizing hypothermic protection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.