Evidence map›Paper›PMID 19833159›Full record

ArticleHuman immunology2010

Sequence variations at the human leukocyte antigen-linked olfactory receptor cluster do not influence female preferences for male odors.

Emma E Thompson, Gabe Haller, Jayant M Pinto, Ying Sun, Bethanne Zelano, Suma Jacob, Martha K McClintock, Dan L Nicolae, Carole Ober

Abstract read
In one paragraph

Article in Human immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Oxytocin and its links through scientific lineage.Comprehensive psychoneuroendocrinology · 2024
    Article
  2. Article
  3. Characterizing novel olfactory receptors expressed in the murine renal cortex.American journal of physiology. Renal physiology · 2019
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Emma E ThompsonDepartment of Human Genetics, The University of Chicago, Chicago, Illinois, USA. eethomps@uchicago.edu
Gabe Haller
Jayant M Pinto
Ying Sun
Bethanne Zelano
Suma Jacob
Martha K McClintock
Dan L Nicolae
Carole Ober

Funding

RESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1M
MOLECULAR GENETIC STUDIES OF FERTILITY IN THE HUTTERITESR01HD021244 · NICHD · UNIVERSITY OF CHICAGO · PI OBER, CAROLE · 1986 to 2011
$3.0M
Understanding Susceptibility to Olfactory Decline in AgingK23AG036762 · NIA · UNIVERSITY OF CHICAGO · PI PINTO, JAYANT M · 2012 to 2014
$457k
NHLBI NIH HHS T32 HL007605NIA NIH HHS K23 AG036762NICHD NIH HHS HD21244NICHD NIH HHS R01 HD021244
6 · The paper itself

Abstract

We previously reported that paternally inherited human leukocyte antigen (HLA) alleles are a template for women's preferences for male odors (p = 0.0007). However, it has been suggested that sequence variation in a nearby olfactory receptor (OR) cluster on chromosome 6p influences smell preference. To determine whether the HLA-linked OR genes contribute to previously observed HLA-mediated behaviors, we use the odor preference data from our earlier study in combination with a new resequencing study of four functional, HLA-linked OR genes in the same subjects. Our results indicate that OR alleles in the genes surveyed are not in linkage disequilibrium with HLA variation and do not explain the previous findings of HLA-associated odor preference.

Indexed as

Multigene FamilyOlfactory PerceptionPolymorphism, Single NucleotideAdolescentAdultBase SequenceChromosomes, Human, Pair 6FemaleGenetic LinkageHLA AntigensHumansMaleMiddle AgedPheromones, HumanReceptors, OdorantSex CharacteristicsHLA AntigensPheromones, HumanReceptors, Odorant

Identifiers

PMID19833159
PMCPMC3631539

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.