ArticleBrain research2010
Influence of 17beta-estradiol and progesterone on GABAergic gene expression in the arcuate nucleus, amygdala and hippocampus of the rhesus macaque.
Article in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- The prenatal sex steroid theory of autism after 25 years.Nature human behaviour · 2026Review
- Castl: robust identification of spatially variable genes in spatial transcriptomics via an ensemble-based framework.Briefings in bioinformatics · 2026Article
- Estrogens produced within the central amygdala inhibit varicella zoster-induced orofacial pain.Journal of neuroendocrinology · 2025Article
- Article
- GABA System Modifications During Periods of Hormonal Flux Across the Female Lifespan.Frontiers in behavioral neuroscience · 2022Review
- Reduced activity of GAD67 expressing cells in the reticular thalamus enhance thalamic excitatory activity and varicella zoster virus associated pain.Neuroscience letters · 2020Article
- LncRNA COL1A1-014 is involved in the progression of gastric cancer via regulating CXCL12-CXCR4 axis.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2020Article
- Estradiol Acts in Lateral Thalamic Region to Attenuate Varicella Zoster Virus Associated Affective Pain.Neuroscience · 2019Article
- Comparison of transitional vs surgical menopause on monoamine and amino acid levels in the rat brain.Molecular and cellular endocrinology · 2018Article
- Gene expression profiling of the SCN in young and old rhesus macaques.Journal of molecular endocrinology · 2018Article
- Aromatase Derived Estradiol Within the Thalamus Modulates Pain Induced by Varicella Zoster Virus.Frontiers in integrative neuroscience · 2018Article
- GABA+ levels in postmenopausal women with mild-to-moderate depression: A preliminary study.Medicine · 2016Article
- Molecular mechanisms underlying the memory-enhancing effects of estradiol.Hormones and behavior · 2015Review
- Association of microtubule associated protein-2, synaptophysin, and apolipoprotein E mRNA and protein levels with cognition and anxiety levels in aged female rhesus macaques.Behavioural brain research · 2012Article
- Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder.PloS one · 2012Article
- The effect of age on the discriminative stimulus effects of ethanol and its GABA(A) receptor mediation in cynomolgus monkeys.Psychopharmacology · 2011Article
- Role of circadian neuroendocrine rhythms in the control of behavior and physiology.Neuroendocrinology · 2011Review
- Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques.Endocrinology · 2010Article
- Microarray analysis of relative gene expression stability for selection of internal reference genes in the rhesus macaque brain.BMC molecular biology · 2010Article
- Gene expression profiling in the rhesus macaque: methodology, annotation and data interpretation.Methods (San Diego, Calif.) · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the brain, and the responsiveness of neurons to GABA can be modulated by sex steroids. To better understand how ovarian steroids influence the GABAergic system in the primate brain, we evaluated the expression of genes encoding GABA receptor subunits, glutamic acid decarboxylase (GAD) and a GABA transporter in the brains of female rhesus macaques. Ovariectomized adults were subjected to a hormone replacement paradigm involving either 17beta-estradiol (E), or E plus progesterone (E+P). Untreated animals served as controls. Using GeneChip microarray analysis and real-time RT-PCR (qPCR), we examined gene expression differences within and between the amygdala (AMD), hippocampus (HPC) and arcuate nuclei of the medial basal hypothalamus (MBH). The results from PCR corresponded with results from representative GeneChip probesets, and showed similar effects of sex steroids on GABA receptor subunit gene expression in the AMD and HPC, and a more pronounced expression than in the MBH. Exposure to E+P attenuated GAD1, GAD2 and SLC32A1 gene expression in the AMD and HPC, but not in the MBH. GABA receptor subunit gene expression was generally higher in the AMD and HPC than in the MBH, with the exception of receptor subunits epsilon and gamma 2. Taken together, the data demonstrate differential regulation of GABA receptor subunits and GABAergic system components in the MBH compared to the AMD and HPC of rhesus macaques. Elevated epsilon and reduced delta subunit expression in the MBH supports the hypothesis that the hypothalamic GABAergic system is resistant to the modulatory effects of sex steroids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.