ReviewBrain pathology (Zurich, Switzerland)2010
Recent insights into PDGF-induced gliomagenesis.
Review in Brain pathology (Zurich, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Phase II study of Gleevec plus hydroxyurea in adults with progressive or recurrent low-grade glioma.Cancer · 2012Trial
- Exploring the Biological Overlapping Between Brain Calcifications and Tumorgenesis.Journal of molecular neuroscience : MN · 2024Article
- Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma.Brain : a journal of neurology · 2021Article
- Insights into molecular therapy of glioma: current challenges and next generation blueprint.Acta pharmacologica Sinica · 2017Review
- Concurrence of Fahr's disease and brain tumor: A case report and review of the literature.Experimental and therapeutic medicine · 2015Article
- Double minute amplification of mutant PDGF receptor α in a mouse glioma model.Scientific reports · 2015Article
- Crosstalk between glioma-initiating cells and endothelial cells drives tumor progression.Cancer research · 2014Article
- Molecular and cellular features of murine craniofacial and trunk neural crest cells as stem cell-like cells.PloS one · 2014Article
- ZIP4 is a novel molecular marker for glioma.Neuro-oncology · 2013Article
- A multi-parametric imaging investigation of the response of C6 glioma xenografts to MLN0518 (tandutinib) treatment.PloS one · 2013Article
- Role of platelet derived growth factor receptor (PDGFR) over-expression and angiogenesis in ependymoma.Journal of neuro-oncology · 2013Article
- PDGF-B-mediated downregulation of miR-21: new insights into PDGF signaling in glioblastoma.Human molecular genetics · 2012Article
- Macropinocytosis of the PDGF β-receptor promotes fibroblast transformation by H-RasG12V.Molecular biology of the cell · 2012Article
- Review: insights gained from modelling high-grade glioma in the mouse.Neuropathology and applied neurobiology · 2012Review
- Article
- Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- PDGF-B exploits stromal EPO.Nature medicine · 2012Article
- Platelet-derived growth factor receptor (PDGFR) expression in primary spinal cord gliomas.Journal of neuro-oncology · 2012Article
- Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.Brain pathology (Zurich, Switzerland) · 2011Review
- Platelet-derived growth factor receptor alpha in glioma: a bad seed.Chinese journal of cancer · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gliomas are aggressive and almost incurable glial brain tumors which frequently display abnormal platelet-derived growth factor (PDGF) signaling. Evidence gained from studies on several in vivo animal models has firmly established a causal connection between aberrant PDGF signaling and the formation of some gliomas. However, only recently has significant knowledge been gained regarding crucial issues such as the glioma cell of origin and the relationship between the transforming stimulus and the cellular characteristics of the resulting tumor. Based on recent evidence, we propose that PDGF can bias cell-fate decisions, driving the acquisition of cell type-specific features by the progeny of multipotent neural progenitors, thus determining the shape and direction of the transformation path. Furthermore, recent data about the cellular mechanisms of PDGF-driven glioma progression and maintenance indicate that PDGF may be required, unexpectedly, to override cell contact inhibition and promote glioma cell infiltration rather than to stimulate cell proliferation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.