Evidence map›Paper›PMID 19830594›Full record

ArticleJournal of structural and functional genomics2010

The E. coli single protein production system for production and structural analysis of membrane proteins.

Lili Mao, S Thangminlal Vaiphei, Tsutomu Shimazu, William M Schneider, Yuefeng Tang, Rajeswari Mani, Monica J Roth, Gaetano T Montelione, Masayori Inouye

Abstract read
In one paragraph

Article in Journal of structural and functional genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Lili MaoCenter for Advanced Technology and Medicine, UMDNJ-Robert Wood Johnson Medical School, 679 Hoes Lane, Piscataway, NJ 08854, USA.
S Thangminlal Vaiphei
Tsutomu Shimazu
William M Schneider
Yuefeng Tang
Rajeswari Mani
Monica J Roth
Gaetano T Montelione
Masayori Inouye
Johnson University · USRutgers, The State University of New Jersey · US

Funding

Sub-project 9U54GM074958 · NIGMS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI ARROWSMITH, CHERYL H · 2005 to 2009
$56.6M
Sub 9 at AECMU54GM075026 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI HENDRICKSON, WAYNE A. · 2005 to 2009
$16.8M
The Method for Determination of Membrane Protein Structures without Purification R01GM085449 · NIGMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI INOUYE, MASAYORI · 2008 to 2011
$1.2M
NIGMS NIH HHS 1R01 GM085449NIGMS NIH HHS R01 GM085449NIGMS NIH HHS U54 GM074958NIGMS NIH HHS U54 GM075026NIGMS NIH HHS U54 GM75026
6 · The paper itself

Abstract

At present, only 0.9% of PDB-deposited structures are of membrane proteins in spite of the fact that membrane proteins constitute approximately 30% of total proteins in most genomes from bacteria to humans. Here we address some of the major bottlenecks in the structural studies of membrane proteins and discuss the ability of the new technology, the Single-Protein Production system, to help solve these bottlenecks.

Indexed as

HumansMembrane ProteinsProteinsMembrane ProteinsProteins

Identifiers

PMID19830594
PMCPMC4190415
OpenAlexW1987168379

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.