ArticleLung2010
Prostanoids and the cough reflex.
Article in Lung, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Structure and transport mechanism of the human prostaglandin transporter SLCO2A1.Nature communications · 2025Article
- Chronic cough associated with statin use in a 74-year-old man.Canadian family physician Medecin de famille canadien · 2025Article
- Characterisation of cough evoked by inhaled treprostinil and treprostinil palmitil.ERJ open research · 2021Article
- Cross-effect of TRPV1 and EP3 receptor on coughs and bronchopulmonary C-neural activities.PloS one · 2021Article
- Peripheral and central mechanisms of cough hypersensitivity.Journal of thoracic disease · 2020Review
- Bradykinin sensitizes the cough reflex via a BRespiratory research · 2019Article
- Article
- Vagal Afferent Innervation of the Airways in Health and Disease.Physiological reviews · 2016Review
- PGE2-treated macrophages inhibit development of allergic lung inflammation in mice.Journal of leukocyte biology · 2016Article
- Proteinase-activated receptors (PARs) - focus on receptor-receptor-interactions and their physiological and pathophysiological impact.Cell communication and signaling : CCS · 2013Review
- Role of PGE2 in asthma and nonasthmatic eosinophilic bronchitis.Mediators of inflammation · 2012Review
- Afferent nerves regulating the cough reflex: mechanisms and mediators of cough in disease.Otolaryngologic clinics of North America · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prostanoids such as prostaglandin (PG) D(2), PGE(2), PGF(2alpha), prostacyclin (PGI(2)), and thromboxane (Tx) A(2) act via five classes of receptors named DP, EP, FP, IP, and TP, respectively, and mediate a diverse range of physiological effects. Prostanoids are commonly associated with many diseases as a proinflammatory mediator; however, in the lung, prostanoids, particularly PGE(2), seem to have a protective role. Inhaled PGE(2) has been shown to be anti-inflammatory and a bronchodilator but causes cough. This has hindered the development of prostanoids for the treatment of airway inflammatory diseases. We discuss here the extensive research into the role of prostanoids in the airways and their modulation of the cough reflex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.