ReviewImmunologic research2010
What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?
Review in Immunologic research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 25 citations in OpenAlex.
- The Amphibian Major Histocompatibility Complex-A Review and Future Outlook.Journal of molecular evolution · 2025Review
- Structure and evolution of the squamate major histocompatibility complex as revealed by twoFrontiers in genetics · 2022Article
- A splice acceptor variant in HLA-DRA affects the conformation and cellular localization of the class II DR alpha-chain.Immunology · 2021Article
- Viral-host interaction in kidney reveals strategies to escape host immunity and persistently shed virus to the urine.Oncotarget · 2017Article
- Comparative analysis of virus-host interactions caused by a virulent and an attenuated duck hepatitis A virus genotype 1.PloS one · 2017Article
- Molecular characterization of MHC class II in the Australian invasive cane toad reveals multiple splice variants.Immunogenetics · 2016Article
- Human Leukocyte Antigen Diversity: A Southern African Perspective.Journal of immunology research · 2015Review
- Mamu-B genes and their allelic repertoires in different populations of Chinese-origin rhesus macaques.Immunogenetics · 2013Article
- Productive association between MHC class I and tapasin requires the tapasin transmembrane/cytosolic region and the tapasin C-terminal Ig-like domain.Molecular immunology · 2012Article
- IL-6 potentiates tumor resistance to photodynamic therapy (PDT).Lasers in surgery and medicine · 2011Article
- CTL recognition of a novel HLA-A*0201-binding peptide derived from glioblastoma multiforme tumor cells.Cancer immunology, immunotherapy : CII · 2011Article
- Peroxiredoxin 1 controls prostate cancer growth through Toll-like receptor 4-dependent regulation of tumor vasculature.Cancer research · 2011Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The expression of major histocompatibility complex (MHC) class I molecules on the cell surface is critical for recognition by cytotoxic T lymphocytes (CTL). This recognition event leads to destruction of cells displaying MHC class I-viral peptide complexes or cells displaying MHC class I-mutant peptide complexes. Before they can be transported to the cell surface, MHC class I molecules must associate with their peptide ligand in the endoplasmic reticulum (ER) of the cell. Within the ER, numerous proteins assist in the appropriate assembly and folding of MHC class I molecules. These include the heterodimeric transporter associated with antigen processing (TAP1 and TAP2), the heterodimeric chaperone-oxidoreductase complex of tapasin and ERp57 and the general ER chaperones calreticulin and calnexin. Each of these accessory proteins has a well-defined role in antigen presentation by MHC class I molecules. However, alternate splice forms of MHC class I heavy chains, TAP and tapasin, have been reported suggesting additional complexity to the picture of antigen presentation. Here, we review the importance of these different accessory proteins and the progress in our understanding of alternate splicing in antigen presentation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.