ArticleJournal of biomedicine & biotechnology2009
Immune responses following mouse peripheral nerve xenotransplantation in rats.
Article in Journal of biomedicine & biotechnology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Challenges and Advances in Peripheral Nerve Tissue Engineering Critical Factors Affecting Nerve Regeneration.Journal of tissue engineering and regenerative medicine · 2024Review
- Comparison of the biological properties between 3D-printed and decellularized tracheal grafts.Bioprocess and biosystems engineering · 2023Article
- Physical processing for decellularized nerve xenograft in peripheral nerve regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- Functional and immunological peculiarities of peripheral nerve allografts.Neural regeneration research · 2022Review
- Comparison of tracheal reconstruction with allograft, fresh xenograft and artificial trachea scaffold in a rabbit model.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2018Article
- The imbalance between Tregs, Th17 cells and inflammatory cytokines among renal transplant recipients.BMC immunology · 2015Article
- Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering.ACS biomaterials science & engineering · 2015Article
- The cellular immune mechanism after transfer of chemically extracted acellular nerve xenografts.PloS one · 2013Article
- A crucial role of IL-17 and IFN-γ during acute rejection of peripheral nerve xenotransplantation in mice.PloS one · 2012Article
- Efficacy and safety of Bio 3D conduits composed of human umbilical cord-derived mesenchymal stromal cells: A proof-of-concept study in a canine ulnar nerve defect model.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenotransplantation offers a potentially unlimited source for tissues and organs for transplantation, but the strong xenoimmune responses pose a major obstacle to its application in the clinic. In this study, we investigate the rejection of mouse peripheral nerve xenografts in rats. Severe intragraft mononuclear cell infiltration, graft distension, and necrosis were detected in the recipients as early as 2 weeks after mouse nerve xenotransplantation. The number of axons in xenografts reduced progressively and became almost undetectable at week 8. However, mouse nerve xenotransplantation only led to a transient and moderate increase in the production of Th1 cytokines, including IL-2, IFN-gamma, and TNF-alpha. The data implicate that cellular immune responses play a critical role in nerve xenograft rejection but that further identification of the major effector cells mediating the rejection is required for developing effective means to prevent peripheral nerve xenograft rejection.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.