ArticleThe Journal of investigative dermatology2010
Agents that reverse UV-Induced immune suppression and photocarcinogenesis affect DNA repair.
Article in The Journal of investigative dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 90 citations in OpenAlex.
- Skin on Drugs: Psychotropic Compounds in Cutaneous Biology.International journal of molecular sciences · 2026Review
- Practical Recommendations for Indians on Sunscreen Use-A Modified Delphi Consensus by Indian Sunscreen Forum (PRISM-ISF).Journal of cosmetic dermatology · 2025Article
- Integrated Analysis Reveals COL4A3 as a Novel Diagnostic and Therapeutic Target in UV-Related Skin Cutaneous Melanoma.Clinical, cosmetic and investigational dermatology · 2024Article
- The Prophylactic Effect of Vitamin C and Vitamin B12 against Ultraviolet-C-Induced Hepatotoxicity in Male Rats.Molecules (Basel, Switzerland) · 2023Article
- Investigation of Metabolome Underlying the Biological Mechanisms of Acute Heat Stressed Granulosa Cells.International journal of molecular sciences · 2022Article
- UVB-Induced Microvesicle Particle Release and Its Effects on the Cutaneous Microenvironment.Frontiers in immunology · 2022Review
- Ethanol consumption synergistically increases ultraviolet radiation induced skin damage and immune dysfunction.Journal of dermatological science · 2021Article
- The Potential Role of Dietary Platelet-Activating Factor Inhibitors in Cancer Prevention and Treatment.Advances in nutrition (Bethesda, Md.) · 2019Review
- From Early Immunomodulatory Triggers to Immunosuppressive Outcome: Therapeutic Implications of the Complex Interplay Between the Wavebands of Sunlight and the Skin.Frontiers in medicine · 2018Review
- Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage.Frontiers in pharmacology · 2018Review
- Platelet activating factor-induced expression of p21 is correlated with histone acetylation.Scientific reports · 2017Article
- Serotonin signalling is crucial in the induction of PUVA-induced systemic suppression of delayed-type hypersensitivity but not local apoptosis or inflammation of the skin.Experimental dermatology · 2016Article
- Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer.Progress in lipid research · 2016Review
- Prevention of Photocarcinogenesis by Agonists of 5-HT1A and Antagonists of 5-HT2A Receptors.Molecular neurobiology · 2016Review
- Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells.Cell death & disease · 2015Article
- Photoimmunology.Dermatologic clinics · 2014Review
- Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy.International journal of molecular sciences · 2013Article
- Exposure to UV Wavelengths in Sunlight Suppresses Immunity. To What Extent is UV-induced Vitamin D3 the Mediator Responsible?The Clinical biochemist. Reviews · 2013Article
- The immunologic revolution: photoimmunology.The Journal of investigative dermatology · 2012Review
- Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis.Carcinogenesis · 2012Article
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
UV exposure induces skin cancer, in part, by inducing immune suppression. Repairing DNA damage, neutralizing the activity of cis-urocanic acid, and reversing oxidative stress abrogate UV-induced immune suppression and skin cancer induction, suggesting that DNA, UCA, and lipid photo-oxidation serve as UV photoreceptors. What is not clear is whether signaling through each of these different photoreceptors activates independent pathways to induce biological effects or whether there is a common checkpoint where these pathways converge. Here, we show that agents known to reverse photocarcinogenesis and photoimmune suppression, such as platelet-activating factor (PAF) and serotonin (5-HT) receptor antagonists, regulate DNA repair. Pyrimidine dimer repair was accelerated in UV-irradiated mice injected with PAF and 5-HT receptor antagonists. Nucleotide excision repair (NER), as measured by unscheduled DNA synthesis, was accelerated by PAF and 5-HT receptor antagonists. Injecting PAF and 5-HT receptor antagonists into UV-irradiated Xeroderma pigmentosum complementation group A-deficient mice, which lack the enzymes responsible for NER, did not accelerate photoproduct repair. Similarly, UV-induced formation of 8-oxo-deoxyguanosine was reduced by PAF and 5-HT receptor antagonists. We conclude that PAF and 5-HT receptor antagonists accelerate DNA repair caused by UV radiation, which prevents immune suppression and interferes with photocarcinogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.